αvβ1 integrin-IN-1 TFA (Compound C8) is a potent and selective αvβ1 integrin inhibitor with an IC50 of 0.63 nM. Antifibrotic effects [1].
In Vitro, αvβ1 integrin-IN-1 TFA (Compound C8) significantly reduces the fibrotic markers in mouse model for liver and lung fibrosis[1].
References:
[1]. Reed NI, et al. Exploring N-Arylsulfonyl-l-proline Scaffold as a Platform for Potent and Selective αvβ1 Integrin Inhibitors. ACS Med Chem Lett. 2016 Aug 30;7(10):902-907.
In Vitro, αvβ1 integrin-IN-1 TFA (Compound C8) significantly reduces the fibrotic markers in mouse model for liver and lung fibrosis[1].
References:
[1]. Reed NI, et al. Exploring N-Arylsulfonyl-l-proline Scaffold as a Platform for Potent and Selective αvβ1 Integrin Inhibitors. ACS Med Chem Lett. 2016 Aug 30;7(10):902-907.