Bis-PEG7-acid |
| Catalog No.GC67118 |
Le bis-PEG7-acide est un lieur PROTAC à base de PEG qui peut être utilisé dans la synthèse des PROTAC. L'acide bis-PEG6-propionique est un lieur ADC clivable utilisé dans la synthèse de conjugués anticorps-médicament (ADC).
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Cas No.: 94376-75-7
Sample solution is provided at 25 µL, 10mM.
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Bis-PEG7-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG6-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
[1]. Marc Stefan ROBILLARD, et al. Tetrazines for high click conjugation yield in vivo and high click release yield. WO2019212356A1
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