c(avb6)-DOTA TFA is a conjugate of the αvβ6 integrin selective peptide ring modified with DOTA chelator. The Lu(III) complex of c(avb6)-DOTA TFA has a comparable affinity for αvβ6 integrin ( IC50 =0.8 nM) and can be used as a tumor diagnostic [1].
References:
[1]. Färber S F, et al. Therapeutic radiopharmaceuticals targeting integrin αvβ6[J]. ACS omega, 2018, 3(2): 2428-2436.
References:
[1]. Färber S F, et al. Therapeutic radiopharmaceuticals targeting integrin αvβ6[J]. ACS omega, 2018, 3(2): 2428-2436.
















