Cefmetazole is a cephamycin antibiotic.1 It is active against E. coli, P. mirabilis, H. influenzae, N. gonorrhoeae, S. pneumoniae, and S. pyogenes (MIC50s = 0.25-2 μg/ml). Cefmetazole (20 and 40 mg/kg per day) decreases the lesion size and the number of ulcerative lesions in a rabbit model of active syphilis.2
1.Jones, R.N., Barry, A.L., Fuchs, P.C., et al.Antimicrobial activity of cefmetazole (CS-1170) and recommendations of susceptibility testing by disk diffusion, dilution, and anaerobic methodsJ. Clin. Microbiol.24(6)1055-1059(1986) 2.Baker-Zander, S.A., and Lukehart, S.A.Efficacy of cefmetazole in the treatment of active syphilis in the rabbit modelAntimicrob. Agents Chemother.33(9)1465-1469(1989)