Desmethylxanthohumol |
Catalog No.GC62927
One-Click Copy Product Info
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Desmethylxanthohumol est un composé de type chalcone isolé du houlon présentant une activité anticancéreuse.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 115063-39-3
Sample solution is provided at 25 µL, 10mM.
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Desmethylxanthohumol est un composé de type chalcone isolé du houlon présentant une activité anticancéreuse[1]. Desmethylxanthohumol peut inhiber la formation des membranes biologiques, perturber la structure des membranes biologiques et inhiber la croissance de diverses bactéries[2]. Desmethylxanthohumol a été largement utilisé pour l'inhibition de la prolifération des cellules cancéreuses de la prostate et dans les analyses comparatives pharmacologiques[3].
Le traitement in vitro avec Desmethylxanthohumol pendant 48h a significativement inhibé la viabilité des cellules endothéliales de la veine ombilicale humaine (HUVECs), sa valeur d'IC50 est 18.92µM[4].
References:
[1] Vogel S, Ohmayer S, Brunner G, et al. Natural and non-natural prenylated chalcones: synthesis, cytotoxicity and anti-oxidative activity[J]. Bioorganic & medicinal chemistry, 2008, 16(8): 4286-4293.
[2] Bocquet L, Sahpaz S, Bonneau N, et al. Phenolic compounds from Humulus lupulus as natural antimicrobial products: new weapons in the fight against methicillin resistant Staphylococcus aureus, Leishmania mexicana and Trypanosoma brucei strains[J]. Molecules, 2019, 24(6): 1024.
[3] Delmulle L, Bellahcene A, Dhooge W, et al. Anti-proliferative properties of prenylated flavonoids from hops (Humulus lupulus L.) in human prostate cancer cell lines[J]. Phytomedicine, 2006, 13(9-10): 732-734.
[4] Teng Y, Li X, Yang K, et al. Synthesis and antioxidant evaluation of desmethylxanthohumol analogs and their dimers[J]. European Journal of Medicinal Chemistry, 2017, 125: 335-345.
| Expériences cellulaires [1]: | |
Lignées cellulaires | HUVECs |
Méthode de préparation | HUVECs ont été cultivées dans un milieu minimum d'Eagle (DMEM) supplémenté avec 10% de sérum de veau foetal à 37°C dans une incubatrice à 5% CO2. Les cellules HUVECs (100μl) ont été cultivées dans des plaques à 96 puits à une densité de 5×103 cellules par puits pendant 24h. Différentes concentrations de Desmethylxanthohumol (0.1, 1, 10, 50, et 100µM) ont été ajoutées à chaque puits pour une culture supplémentaire de 48h. Ensuite, la viabilité cellulaire a été analysée. |
Conditions de réaction | 0.1, 1, 10, 50, et 100µM; 48h |
Domaines d'application | Le traitement avec Desmethylxanthohumol a réduit considérablement la mort cellulaire de HUVECs de manière dépendante de la dose. |
References: | |
| Cas No. | 115063-39-3 | SDF | |
| Formula | C20H20O5 | M.Wt | 340.37 |
| Solubility | Storage | Store at 2-8°C,protect from light | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.938 mL | 14.6899 mL | 29.3798 mL |
| 5 mM | 587.6 μL | 2.938 mL | 5.876 mL |
| 10 mM | 293.8 μL | 1.469 mL | 2.938 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 1 reference(s) in Google Scholar.)