Dutogliptin |
| Catalog No.GC31467 |
La dutogliptine (base libre PHX-1149) est un inhibiteur de la dipeptidyl peptidase-4 (DPP4) disponible par voie orale, puissant et sélectif pour le traitement du diabète sucré de type 2.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 852329-66-9
Sample solution is provided at 25 µL, 10mM.
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Dutogliptin is an orally available, potent, and selective dipeptidyl peptidase-4 (DPP4) inhibitor.
Dutogliptin is highly water soluble (>2000 mg/mL), has low cellular permeability, exhibits low plasma protein binding (11%) and is rapidly absorbed with a Tmax of 3-4 h and a half-life of 10-13 h. The compound is metabolically stable and does not inhibit or induce the activity of major CYP450s[2].
[1]. Marier JF, et al. Population pharmacokinetic analysis of dutogliptin, a selective dipeptidyl peptidase-4 inhibitor. Clin Pharmacol Drug Dev. 2014 Jul;3(4):297-304. [2]. Pattzi HM, et al. Dutogliptin, a selective DPP4 inhibitor, improves glycaemic control in patients with type 2 diabetes: a 12-week, double-blind, randomized, placebo-controlled, multicentre trial. Diabetes Obes Metab. 2010 Apr;12(4):348-55.
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)
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