LY 345899 |
| Catalog No.GC31357 |
LY 345899 est un analogue de l'acide folique et est un inhibiteur de la méthylène tétrahydrofolate déshydrogénase (MTHFD1 ; DC301) et MTHFD2 avec des valeurs IC50 de 96 nM et 663 nM, respectivement, ainsi qu'un Ki de 18 nM pour MTHFD1.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 10538-99-5
Sample solution is provided at 25 µL, 10mM.
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LY 345899 is a human cytosolic methylenetetrahydrofolate dehydrogenase/cyclohydrolase (DC301) inhibitor, with a Ki of 0.018 μM.
[1]. Schmidt A, et al. Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase. Biochemistry. 2000 May 30;39(21):6325-35.
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