Episterol is an Ergosterol biosynthetic intermediate. Episterol replaces Ergosterol as the major sterol in Saccharomyces cerevisiae Δerg3 mutants, confers resistance to combined lethal and vacuole-disruptive actions of Amphotericin B and MC12 [1].
In Vitro, Episterol accumulation in Saccharomyces cerevisiae Δerg3 mutant cells eliminates the synergistic antifungal activity between Amphotericin B and MC12, resulting in an indifferent drug interaction with an FIC index of 2.00[1].
References:
[1]. Kang CK, et al. Visualization analysis of the vacuole-targeting fungicidal activity of amphotericin B against the parent strain and an ergosterol-less mutant of Saccharomyces cerevisiae. Microbiology (Reading). 2013;159(Pt 5):939-947.
In Vitro, Episterol accumulation in Saccharomyces cerevisiae Δerg3 mutant cells eliminates the synergistic antifungal activity between Amphotericin B and MC12, resulting in an indifferent drug interaction with an FIC index of 2.00[1].
References:
[1]. Kang CK, et al. Visualization analysis of the vacuole-targeting fungicidal activity of amphotericin B against the parent strain and an ergosterol-less mutant of Saccharomyces cerevisiae. Microbiology (Reading). 2013;159(Pt 5):939-947.