Fenoprofen-13C6 is intended for use as an internal standard for the quantification of fenoprofen by GC- or LC-MS. Fenoprofen is a non-steroidal anti-inflammatory drug (NSAID).1 It inhibits spontaneous and estradiol-stimulated prostaglandin F2α (PGF2α) release by 84% in isolated rat uterine horns when used at a concentration of 33 μM. Fenoprofen (10 mg/kg, i.p.) reduces serum PGF2α levels in rats. It reduces acetic acid-induced writhing and stretching and formalin-induced licking behaviors in mice, however, it also induces the formation of gastric lesions in mice.2 Formulations containing fenoprofen have been used in the treatment of pain and the signs and symptoms of rheumatoid arthritis and osteoarthritis.
References:
[1]. Patrono, C., Ciabattoni, G., and Grossi-Belloni, D.In vitro and in vivo inhibition of prostaglandin synthesis by fenoprofen, a non steroid anti-inflammatory drugPharmacol. Res. Commun.6(5)509-518(1974).
[2]. Agotegaray, M., Gumilar, F., Boeris, M., et al.Enhanced analgesic properties and reduced ulcerogenic effect of a mononuclear copper(II) complex with fenoprofen in comparison to the parent drug: Promising insights in the treatment of chronic inflammatory diseasesBiomed. Res. Int.505987(2014).