F-1 |
| Catalog No.GC36021 |
F-1 est un puissant inhibiteur double ALK et ROS1, supprime phospho-ALK et ses voies de signalisation en aval relatives, avec des IC50 de 2,1 nM, 2,3 nM, 1,3 nM et 3,9 nM pour ALKWT, ROS1WT, ALKL1196M et ALKG1202R, respectivement.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2244775-31-1
Sample solution is provided at 25 µL, 10mM.
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F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathways, with IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively[1].
[1]. Guo M, et al. Dual potent ALK and ROS1 inhibitors combating drug-resistant mutants: Synthesis and biological evaluation of aminopyridine-containing diarylaminopyrimidine derivatives. Eur J Med Chem. 2018 Sep 6;158:322-333.
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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