Isosilybin A |
| Catalog No.GC36343 |
L'isosilybine A, un flavonolignan isolé de la silymarine, a une activité anti-cancer de la prostate (PCA). L'isosilybine A inhibe la prolifération et induit l'arrêt de la phase G1 et l'apoptose dans les cellules cancéreuses, ce qui active la machinerie apoptotique dans les cellules PCA via le ciblage de l'axe Akt-NF-κB-récepteur aux androgènes (AR).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 142796-21-2
Sample solution is provided at 25 µL, 10mM.
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Isosilybin A, a flavonolignan isolated from silymarin, has anti-prostate cancer (PCA) activity. Isosilybin A inhibits proliferation and induces G1 phase arrest and apoptosis in cancer cells, which activates apoptotic machinery in PCA cells via targeting Akt-NF-κB-androgen receptor (AR) axis[1][2].
[1]. Deep G, et al. Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostatecancer LNCaP and 22Rv1 cells. Carcinogenesis. 2007 Jul;28(7):1533-42. [2]. Deep G, et al. Isosilybin A induces apoptosis in human prostate cancer cells via targeting Akt, NF-κB, and androgen receptor signaling. Mol Carcinog. 2010 Oct;49(10):902-12.
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