Prasugrel Maleic acid |
| Catalog No.GC36957 |
Prasugrel (PCR 4099) L'acide maléique est une thiénopyridine et un promédicament, inhibe la fonction plaquettaire.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 389574-20-3
Sample solution is provided at 25 µL, 10mM.
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Prasugrel (PCR 4099) Maleic acid is a platelet inhibitor with IC50 value of 1.8 μM. P2Y12 receptor.
Prasugrel (PCR 4099) is a novel platelet inhibitor used for the reduction of thrombotic cardiovascular events (including stent thrombosis) in patients with acute coronary syndrome who are to be managed with PCI [2].Prasugrel (PCR 4099) reduces the aggregation ("clumping") of platelets by irreversibly binding to P2Y12 receptors. In rat platelets, prasugrel Maleic acid AM inhibited in vitro platelet aggregation induced by ADP (10 μm) with an IC50 value of 1.8 μm [2].
[1]. Baker WL, et al. Role of prasugrel, a novel P2Y(12) receptor antagonist, in the management of acute coronary syndromes. Am J Cardiovasc Drugs. 2009;9(4):213-29. [2]. Sugidachi A, et al. The greater in vivo antiplatelet effects of prasugrel as compared to clopidogrel reflect more efficient generation of its active metabolite with similar antiplatelet activity to that of clopidogrel's active metabolite. J Thromb Haemost. 2007 Jul;5(7):1545-51. Epub 2007 Apr 19.
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