IDH889 |
| Catalog No.GC38640 |
IDH889 est un inhibiteur spécifique de l'isocitrate déshydrogénase 1 (IDH1) disponible par voie orale, pénétrant dans le cerveau, allostérique et mutant. IDH889 a une puissante sélectivité pour les mutations IDH1 R132 *, avec des IC50 de 0,02 μM, 0,072 μM et 1,38 μM pour IDH1R132H, IDH1R132C et IDH1wt, respectivement. IDH889 montre une puissante inhibition cellulaire de la production de R-2-hydroxyglutarate (2-HG) avec une IC50 de 0,014 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1429179-07-6
Sample solution is provided at 25 µL, 10mM.
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IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1). IDH889 has potent selectivity for IDH1 R132* mutations, with IC50s of 0.02 μM, 0.072 μM and 1.38 μM for IDH1R132H, IDH1R132C and IDH1wt, respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC50 of 0.014 μM[1].
[1]. Levell JR, et al. Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1. ACS Med Chem Lett. 2016 Dec 16;8(2):151-156.
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