Glutaric acid |
| Catalog No.GC33814 |
L'acide glutarique, acide dicarboxylique en C5, est un intermédiaire au cours des voies cataboliques de la lysine et du tryptophane.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 110-94-1
Sample solution is provided at 25 µL, 10mM.
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Glutaric acid induces oxidative stress in brain of young rats.
Glutaric acid (GA) at concentrations of 1 and 2 mM is able to reduce TRAP measurement by up to 28% in a dose-dependent manner (β=0.77; P<0.001). Furthermore, a significantly inverse correlation is also verified between chemiluminescence and TRAP (β=0.81; P<0.001). Glutaric acid does not alter the activities of Cat and SOD, but strongly inhibits (up to 46%) the activity of GPx even at the lower concentration used (0.5 mM). It is observed that the metabolite inhibits this activity in a dose-dependent manner at concentrations as low as 0.05 mM[1].
[1]. de Oliveira Marques F, et al. acid induces oxidative stress in brain of young rats. Brain Res. 2003 Feb 21;964(1):153-8.
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