HTS13286 is a novel AQP9 inhibitor. HTS13286 prevents the LPS-induced increase of NO. HTS13286 reduces glucose output. HTS13286 can be used in the research of endotoxin shock [1].
References:
[1]. Jelen S, et al. Aquaporin-9 protein is the primary route of hepatocyte glycerol uptake for glycerol gluconeogenesis in mice. J Biol Chem. 2011 Dec 30;286(52):44319-25.
[2]. Tesse A, et al. Aquaporin-9 (AQP9) exerts a role in the early phase of the systemic inflammation of a murine model of endotoxic shock[J]. Physiology, 2024, 39(S1): 1193.
References:
[1]. Jelen S, et al. Aquaporin-9 protein is the primary route of hepatocyte glycerol uptake for glycerol gluconeogenesis in mice. J Biol Chem. 2011 Dec 30;286(52):44319-25.
[2]. Tesse A, et al. Aquaporin-9 (AQP9) exerts a role in the early phase of the systemic inflammation of a murine model of endotoxic shock[J]. Physiology, 2024, 39(S1): 1193.