mNLS-CPP-WSTF TFA is the trifluoroacetate salt of mNLS-CPP-WSTF. mNLS-CPP-WSTF is a nuclear localization signal (NLS)-cell-penetrating peptide based on the mouse WSTF sequence. mNLS-CPP-WSTF significantly inhibits the GABARAP-WSTF interaction, WSTF degradation and inflammatory gene expression. mNLS-CPP-WSTF effectively attenuates chronic inflammation, liver fibrosis and cartilage damage in metabolic-dysfunction-associated steatohepatitis (MASH) and osteoarthritis (OA) mice model. mNLS-CPP-WSTF is promising for research of chronic inflammatory diseases such as MASH and OA [1].
References:
[1]. Wang Y, et al. WSTF nuclear autophagy regulates chronic but not acute inflammation. Nature. 2025 Jul 2.
References:
[1]. Wang Y, et al. WSTF nuclear autophagy regulates chronic but not acute inflammation. Nature. 2025 Jul 2.