MSG 606 |
Catalog No.GC50303
One-Click Copy Product Info
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MSG 606 a une activité antagoniste puissante et une sélectivité pour le récepteur de la mélanocortine 1 humain (hMC1R) (IC50 = 17 nM).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1416983-77-1
Sample solution is provided at 25 µL, 10mM.
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MSG 606 a une activité antagoniste puissante et une sélectivité pour le récepteur de la mélanocortine 1 humain (hMC1R) (IC50 = 17 nM) [1].
MSG-606 est une excellente sonde pour cibler spécifiquement les cellules de mélanome pour le diagnostic du cancer de la peau. MSG-606 agit comme antagoniste des cellules de mélanome. Activités de liaison et de cAMP de MSG-606 contre les cellules de mélanome humain (A375) avec un IC50 de 96 nM [1].
MSG-606 (1 nmol/µl, 6 µl) a aboli les effets neuroprotecteurs du système BMS-470539/MC1R, dans un modèle d'hémorragie sous-arachnoïdienne (SAH) [2].
References:
[1]:Cai M, Stankova M, Muthu D, et al. An unusual conformation of γ-melanocyte-stimulating hormone analogues leads to a selective human melanocortin 1 receptor antagonist for targeting melanoma cells[J]. Biochemistry, 2013, 52(4): 752-764.
[2]:Xu, W., Mo, J., Ocak, U. et al. Activation of Melanocortin 1 Receptor Attenuates Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage viathe Suppression of Neuroinflammation through AMPK/TBK1/NF-κB Pathway in Rats. Neurotherapeutics 17, 294-308 (2020). https://doi.org/10.1007/s13311-019-00772-x
| Expériences animales [1]: | |
Modèles animaux | Rats mâles Sprague-Dawley (SD) |
Méthode de préparation | Les rats ont été répartis aléatoirement en cinq groupes : témoin, HSA + véhicule 1 (10 µl de solution saline stérile, i.n.), HSA + BMS-470539 (160 µg/kg, 10 µl), HSA + BMS-470539 + véhicule 2 (6 µl de solution saline stérile, i.c.v.), et HSA + BMS-470539 + MSG-606 (1 nmol/µl, 6 µl). Le MSG-606 a été administré 1 heure avant l'HSA par voie i.c.v. Les tests neurologiques ont été effectués 24 heures après l'HSA. Le cortex cérébral ipsilatéral/gauche a été prélevé pour des analyses de western blot. |
Forme de dosage | 1 nmol/µl, 6 µl, i.c.v. |
Domaines d'application | L'inhibition du récepteur MC1R avec le MSG-606 a significativement aboli les effets anti-inflammatoires du BMS-470539 comparé au groupe HSA + BMS-470539 + véhicule 2. |
Références : [1] : Xu, W., Mo, J., Ocak, U. et al. Activation of Melanocortin 1 Receptor Attenuates Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage via the Suppression of Neuroinflammation through AMPK/TBK1/NF-κB Pathway in Rats. Neurotherapeutics 17, 294-308 (2020). https://doi.org/10.1007/s13311-019-00772-x | |
| Cas No. | 1416983-77-1 | SDF | |
| Canonical SMILES | NC(=O)CNC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CSCCCC(=O)NCC(=O)N[C@@H](CC2=CNC=N2)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC2=CNC3=C2C=CC=C3)C(=O)N1 | ||
| Formula | C62H82N20O13S | M.Wt | 1347.51 |
| Solubility | Soluble in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 742.1 μL | 3.7105 mL | 7.4211 mL |
| 5 mM | 148.4 μL | 742.1 μL | 1.4842 mL |
| 10 mM | 74.2 μL | 371.1 μL | 742.1 μL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 4 reference(s) in Google Scholar.)