NH-bis-PEG2 |
| Catalog No.GC67456 |
Le NH-bis-PEG2 est un lieur PEG ADC non clivable à 2 unités utilisé dans la synthèse de conjugués anticorps-médicament (ADC). Le NH-bis-PEG2 est également un lieur PROTAC à base de PEG qui peut être utilisé dans la synthèse des PROTAC.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 54384-47-3
Sample solution is provided at 25 µL, 10mM.
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NH-bis-PEG2 is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). NH-bis-PEG2 is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[1]. Brown A, et al. PEG-lipid micelles enable cholesterol efflux in Niemann-Pick Type C1 disease-based lysosomal storage disorder. Sci Rep. 2016 Aug 30;6:31750.
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