PPA-037 TFA is an orally active, highly potent and selective inhibitor of cyclin-dependent kinase 12 ( CDK12 ). PPA-037 TFA induces the degradation of cyclin K (Cyclin K), enhancing antiproliferative effects on tumor cells. PPA-037 TFA is promising for research of cancers [1].
References:
[1]. Edward AINSCOW, et al. Substituted pyrazolo[1,5-a]pyrimidine-7-amine compounds as cdk inhibitors and their therapeutic use. WO2022263604A1. 2022-12-22
References:
[1]. Edward AINSCOW, et al. Substituted pyrazolo[1,5-a]pyrimidine-7-amine compounds as cdk inhibitors and their therapeutic use. WO2022263604A1. 2022-12-22