(R)-SARM1-IN-5 is the (R)-enantiomer of SARM1-IN-5. SARM1-IN-5 (compound 1-23-a) is a SARM1 inhibitor. SARM1-IN-5 can be used in the study of axonal degeneration related diseases such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS) [1].
References:
[1]. Jennifer Anne Mcmahon, et al. (s)-3-((6-fluoropyridin-3-yl)methyl)-1-(5-(pyridin-4-yl)-4h-1,2,4-triazol-3-yl)piperidin-2-one benzenesulfonate. WO2025049184. 2025-03-06.
References:
[1]. Jennifer Anne Mcmahon, et al. (s)-3-((6-fluoropyridin-3-yl)methyl)-1-(5-(pyridin-4-yl)-4h-1,2,4-triazol-3-yl)piperidin-2-one benzenesulfonate. WO2025049184. 2025-03-06.