Adaptive Immunity

BMS 470539 (hydrochloride) est un agoniste du récepteur mélanocortine-1 (MC-1R) hautement sélectif et puissant. Dans les dosages d'accumulation d' AMP cyclique (cAMP), ses valeurs d'EC50 sont respectivement 16.8 et 11.6nM pour MC1R humain et murin.

C12 Galactosylceramide is a bioactive sphingolipid.

C16 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from C16 lactosylceramide.

C18 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from lactosylceramide.

C4 Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides.

The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2.

CCR4 antagonist is an antagonist of CC chemokine receptor 4 (CCR4) that inhibits human CCL22-derived [35S]GTPγS and [125I]CCL22 binding in vitro (IC50s = 19 and 70 nM, respectively).

L'inhibiteur de Chk2 (composé 1) est un inhibiteur puissant et sélectif de la kinase de point de contrÔle 2 (Chk2), avec des IC50 de 13,5 nM et 220,4 nM pour Chk2 et Chk1, respectivement. L'inhibiteur de Chk2 peut provoquer un fort effet de radioprotection médié par Chk2 dépendant de l'ataxie télangiectasie (ATM).

Cochlioquinone A, a bioactive compound isolated from D.

Concanamycin B is a macrolide antibiotic that selectively inhibits vacuolar type H+-ATPases, also known as V-ATPases (IC50 = 5 nM).

Cyclic di-IMP (sodium salt) (c-di-IMP) is a synthetic second messenger structurally related to the bacterial second messengers cyclic di-GMP and cyclic di-AMP.

La cyclosporine B est un groupe d'oligopeptides cycliques non polaires À activité immunosuppressive.

Dimethyldioctadecylammonium (DDA) is a cationic amphipathic lipid.

Feglymycin is a 13-amino acid peptide originally isolated from Streptomyces that has antibacterial and antiviral activities.

FTY720 est un modulateur immunitaire qui régule à la baisse les récepteurs de sphingosine-1-phosphate (S1P), renforce l'activité du transporteur de sphingosine ABCB1 et du transporteur de leucotriène C4 ABCC1, et inhibe l'activité de la phospholipase A2 cytosolique.

Galactosylcerebrosides are glycosphingolipids that contain a galactose attached to a ceramide acylated with a hydroxy or non-hydroxy fatty acid.

Galactosylcerebrosides are glycosphingolipids that contain a galactose attached to a ceramide acylated with a hydroxy or non-hydroxy fatty acid.

Ganglioside GM1 asialo is a component of cellular lipid rafts and can be formed by the cleavage of the sialic acid residue from ganglioside GM1 by neuraminidase.

Gemcitabine-13C,15N2 is intended for use as an internal standard for the quantification of gemcitabine by GC- or LC-MS.

Halofuginone is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D.

HDMAPP is a metabolite of the microbial dioxyxylulose-phosphate pathway, which is analogous to the isopentenyl pyrophosphate pathway in mammals.

Hydroxy Ebastine is an ebastine metabolite.

JJH260 is an N-hydroxy hydantoin carbamate that inhibits androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs).

La leucinostatine A (antibiotique P168) est un nonapeptide exerÇant une activité remarquable notamment contre Candida albicans et Cryptococcus neoformans.