Leucinostatin A (Synonyms: P168) |
| Catalog No.GC44050 |
La leucinostatine A (antibiotique P168) est un nonapeptide exerÇant une activité remarquable notamment contre Candida albicans et Cryptococcus neoformans.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 76600-38-9
Sample solution is provided at 25 µL, 10mM.
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Leucinostatin A is a fungal metabolite originally isolated from P. lilacinus with diverse biological activities. It is active against P. oryzae, B. cinera, P. chrysogenum, X. oryzae, S. cerevisiae, and C. albicans fungi and B. subtilis, S. aureus, S. lutea, and M. phlei bacteria in a disc assay. Leucinostatin A (0.1-1 μg/ml) reduces T cell activation induced by phorbol 12-myristate 13-acetate or an anti-CD3 antibody in a concentration-dependent manner. It inhibits proliferation of DU145 prostate cancer cells co-cultured with PrSC stromal cells in vitro (IC50 = 0.045 μg/ml).
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