RWJ 63556 is an orally active COX-2 selective/5-lipoxygenase inhibitor, with anti-inflammatory activities.
RWJ 63556 is a potent inhibitor of leukocyte influx over a period of 24 hr and maintains its in vitro profile on eicosanoids[1].
RWJ 63556 (1 mg/kg, i.v.) significantly inhibits the development of SP-induced oedema[2].
[1]. Kirchner T, et al. Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation. J Pharmacol Exp Ther. 1997 Aug;282(2):1094-101. [2]. Le Filliatre G, et al. Cyclo-oxygenase and lipoxygenase pathways in mast cell dependent-neurogenic inflammation induced by electrical stimulation of the rat saphenous nerve. Br J Pharmacol. 2001 Apr;132(7):1581-9.