(S)-HPMPA is an antiviral agent. (S)-HPMPA can bind to and interfere with viral DNA polymerase activity, thereby inhibiting viral DNA synthesis. (S)-HPMPA can be used for the study of DNA viruses [1] [2].
In Vitro, (S)-HPMPApp is a good substrate for vaccinia DNA polymerase, readily incorporating into the DNA strand without causing strand termination; instead, it exerts its inhibitory effect by inhibiting 3'-to-5' exonuclease activity and blocking template strand elongation[1]. (S)-HPMPA (1-100 μg/mL, 24-72 h) can effectively inhibit viral replication in primary rabbit kidney cells[2].
References:
[1]. Hostetler KY. Alkoxyalkyl prodrugs of acyclic nucleoside phosphonates enhance oral antiviral activity and reduce toxicity: current state of the art. Antiviral Res. 2009 May;82(2):A84-98.
[2]. De Clercq E, et al. A novel selective broad-spectrum anti-DNA virus agent. Nature. 1986 Oct 2-8;323(6087):464-7.
In Vitro, (S)-HPMPApp is a good substrate for vaccinia DNA polymerase, readily incorporating into the DNA strand without causing strand termination; instead, it exerts its inhibitory effect by inhibiting 3'-to-5' exonuclease activity and blocking template strand elongation[1]. (S)-HPMPA (1-100 μg/mL, 24-72 h) can effectively inhibit viral replication in primary rabbit kidney cells[2].
References:
[1]. Hostetler KY. Alkoxyalkyl prodrugs of acyclic nucleoside phosphonates enhance oral antiviral activity and reduce toxicity: current state of the art. Antiviral Res. 2009 May;82(2):A84-98.
[2]. De Clercq E, et al. A novel selective broad-spectrum anti-DNA virus agent. Nature. 1986 Oct 2-8;323(6087):464-7.