SI-2 hydrochloride (Synonyms: EPH 116 hydrochloride) |
Catalog No.GC50307 |
Le SI-2 (chlorhydrate d'EPH 116) est un inhibiteur de SRC-3 (IPP) très prometteur, avec des valeurs IC50 de 3 À 20 nM pour la mort cellulaire du cancer du sein. Le SI-2 (chlorhydrate d'EPH 116) a une toxicité et un profil pharmacocinétique nettement améliorés, avec une disponibilité orale acceptable.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1992052-49-9
Sample solution is provided at 25 µL, 10mM.
Potent steroid receptor coactivator 3 (SRC-3) inhibitor. Reduces SRC1, SRC2 and SRC3 levels in breast cancer cell lines. Inhibits cell growth (IC50 = 3.4 nM), induces apoptosis and attenuates migration of MDA-MB48 breast cancer cells in vitro. Inhibits tumor growth in a MDA-MB48 cell breast cancer mouse model. Orally available.
Song et al (2016) Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proc.Natl.Acad.Sci.U.S.A. 113 4970 PMID:27084884
Average Rating: 5
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