Other Signal Transduction

GATA4-NKX2-5-IN-1 (3i-1000) is a small-molecule compound inhibiting GATA4 and NKX2-5 transcriptional synergy with IC50 of 3 uM

Panx-1 mimetic inhibitory peptide, blocks pannexin-1 gap junctions

Eeyarestatin I, un puissant inhibiteur de la dégradation des protéines associée au réticulum endoplasmique (ERAD), est un puissant inhibiteur de la translocation des protéines. Il perturbe l'homéostasie du réticulum endoplasmique (RE) et a des activités anticancéreuses qui ressemblent à celles du bortézomib. Eeyarestatin I inhibe le translocon Sec61.

10Panx est un puissant inhibiteur du canal Panx1, qui cible la zone W74 à Y83 de la boucle extracellulaire 1 (ECL1) de la protéine Panx1.

Le lévétiracétam, un agent antiépileptique, se lie À la protéine de la vésicule synaptique SV2A.

BLU-782 est un inhibiteur actif par voie orale de la kinase 2 de type récepteur de l'activine (ALK2), ses valeurs d'IC50 sont respectivement 0.2nM, 0.6nM, 3nM, 24nM, 45nM, 65nM, et 155nM pour ALK2 R206H , ALK2, ALK1, ALK6, ALK3, ALK4, et ALK5.

M2N12 est un inhibiteur puissant et hautement sélectif de la protéine phosphatase 25C du cycle de division cellulaire (Cdc25C) avec une valeur IC50 de 0,09 μM. M2N12 a également une activité prometteuse contre Cdc25A et Cdc25B avec des valeurs IC50 de 0,53 μM et 1,39 μM, respectivement. M2N12 a une activité anti-tumorale et peut être utilisé pour la recherche sur le cancer.

LP-935509 est un inhibiteur par voie orale, puissant, sélectif, compétitif de l'ATP et pénétrant dans le cerveau de la kinase associée à la protéine adaptatrice 2 (AAK1) avec une IC50 de 3,3 nM et un Ki de 0,9 nM respectivement.

Decursinol angelate is a pyranocoumarin that has been found in the Korean medicinal herb A.

Compound 43 TAO kinase inhibitor is an ATP-competitive inhibitor of the thousand-and-one amino acid kinases TAOK1 and TAOK2 (IC50s = 11 and 15 nM, respectively).

Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling.

D-myo-inositol-1,2,3,5,6-pentaphosphate (Ins(1,2,3,5,6)-P5) (sodium salt) is produced from Ins(1,2,3,4,5,6)P6 via a minor enzymatic phytate degradation pathway by K.

D-myo-Inositol-1,2,3,5-tetraphosphate (Ins(1,2,3,5)P4) is one of the many inositol phosphate isomers that could act as small, soluble second messengers in the transmission of cellular signals.

D-myo-Inositol-1,2,4,5,6-pentaphosphate (sodium salt) (Ins(1,2,4,5,6)P5 (sodium salt)) is one of several different inositol oligophosphate isomers implicated in signal transduction.

Ins(1,2,4,5)P4 is one of the many inositol phosphate (InsP) isomers that act as small, soluble second messengers in the transmission of cellular signals..

D-myo-Inositol-1,2,6-phosphate (Ins(1,2,6)-P3) is a member of the inositol phosphate (InsP) family of second messengers that play a critical role in the transmission of cellular signals.

The phosphatidylinositol 3-kinase (PI3K)/Akt signal transduction pathway plays critical roles in cell growth and proliferation making it an attractive target for anticancer agents.

The inositol phosphates play a critical role as small, soluble second messengers in transmission of cellular signals.

D-myo-Inositol-1,3,5-phosphate (Ins(1,3,5)P3) is a member of the inositol phosphate (InsP) family of second messengers that play a critical role in the transmission of cellular signals.

D-myo-Inositol-1,4-phosphate (Ins(1,4)P2) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals.

D-myo-Inositol-1,5-phosphate (Ins(1,5)P) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals.

D-myo-Inositol-1-phosphate (Ins(1)P1) is a member of the inositol phosphate molecular family of second messengers that play critical roles in intracellular signaling.

D-myo-Inositol-1-phosphate (Ins(1)P1) is a member of the inositol phosphate (InsP) molecular family of second messengers that play a critical role in the transmission of cellular signals.

D-myo-inositol-2,3,5,6-tetraphosphate (sodium salt) (Ins(2,3,5,6)-P4 (sodium salt)) is produced from Ins(1,2,3,5,6)P5 via a minor enzymatic phytate degradation pathway by K.