Tenofovir diphosphate triethylamine (Synonyms: TFV-DP triethylamine) |
| Catalog No.GC60358 |
Le ténofovir diphosphate triéthylamine (TFV-DP triéthylamine) est un inhibiteur compétitif des ADN polymérases (par rapport au dATP) et un substrat de la transcriptase inverse (RT) du VIH de type 1 (VIH-1).
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Cas No.: 2122333-63-3
Sample solution is provided at 25 µL, 10mM.
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Tenofovir diphosphate triethylamine (TFV-DP triethylamine) is a competitive DNA polymerases inhibitor (with respect to dATP) and a substrate of HIV type 1 (HIV-1) reverse transcriptase (RT)[1].
Tenofovir diphosphate acts as an inhibitor of DNA pol. Tenofovir-diphosphate is a weak inhibitor of DNA polymerases (pol) α, δ, and ?, with values for the Ki for PMPApp (PMPAppKi) relative to the Km for dATP (dATPKm) of 10.2, 10.2, and 15.6, respectively[1].
[1]. Gabriel Birkus, et al. Tenofovir Diphosphate Is a Poor Substrate and a Weak Inhibitor of Rat DNA Polymerases Alpha, Delta, and epsilon. Antimicrob Agents Chemother. 2002 May;46(5):1610-3.
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