UCHL1-IN-1 (Compound 46) is an inhibitor for Ubiquitin C-terminal drolase L1 (UCHL1), with an IC50 of 5.1 μM. UCHL1-IN-1 can be used for cancer research.
UCHL1-IN-1 (0-50 μM, 4 h) inhibits UCHL1 in BT549 cell[1].UCHL1-IN-1 (0-50 μM, 24 h) inhibits cell migration and cell viability in BT549 cell[1].UCHL1-IN-1 is relatively metabolically stable in human liver microsomes assay, with a t1/2 > 120 min, and low intrinsic hepatic clearance[1].
References:
[1]. Imhoff RD, et al. Covalent Fragment Screening and Optimization Identifies the Chloroacetodrazide Scaffold as Inhibitors for Ubiquitin C-terminal drolase L1. J Med Chem. 2024 Mar 15.