VU6083859 is a blood-brain barrier-permeable TAOK1 inhibitor with an IC50 of 158 nM. VU6083859 selectively inhibits TAOK1, exhibits only weak or no activity against TAOK2 and TAOK3, and shows high selectivity for a variety of other kinases. VU6083859 is applicable to research related to neurodevelopmental disorders and tauopathies.
In Vivo, VU6083859 shows central nervous system penetration with a Kp of 0.15, a half-life of 0.94 h, and a plasma clearance of 53.7 mL/min/kg in rats[1].
References:
[1]. Schultz DC, et al. Discovery of VU6083859, a TAOK1 Selective Inhibitor, and VU6080195, a pan -TAOK Activator. ACS Chem Neurosci. 2026;17(3):624-634.
In Vivo, VU6083859 shows central nervous system penetration with a Kp of 0.15, a half-life of 0.94 h, and a plasma clearance of 53.7 mL/min/kg in rats[1].
References:
[1]. Schultz DC, et al. Discovery of VU6083859, a TAOK1 Selective Inhibitor, and VU6080195, a pan -TAOK Activator. ACS Chem Neurosci. 2026;17(3):624-634.