Y 11 (Synonyms: FAK Inhibitor 10) |
| Catalog No.GC14489 |
Y 11 inhibe l'autophosphorylation de FAK1 en bloquant la phosphorylation de Y397 et diminue la croissance tumorale.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1086639-59-9
Sample solution is provided at 25 µL, 10mM.
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Focal adhesion kinases (FAKs) are non-receptor tyrosine kinases that play roles in regulating diverse processes, including cell adhesion, spreading, migration, proliferation, and apoptosis. They are over-expressed in many types of cancer. Y11 inhibits FAK1 autophosphorylation by blocking phosphorylation of Y397.[1] At 100 µM, it was shown to decrease cell viability of T47D breast cancer and C8161 melanoma cell lines.[1]
Reference:
[1]. Golubovskaya, V.M., Nyberg, C., Zheng, M., et al. A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the Y397 site of focal adhesion kinase decreases tumor growth. J. Med. Chem. 51(23), 7405-7416 (2008).
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