(Leu¹⁵)-Gastrin I (human) is a Gastrin I peptide hormone derivative that can cross-link to plasma membranes or intact parietal cells[1]. (Leu¹⁵)-Gastrin I can serve as a key component of the culture medium to induce the differentiation of human adipose-derived stem cells (hASCs) and cultivate liver organoids[2]. (Leu¹⁵)-Gastrin I has been widely used as an internal reference to optimize the HPLC analysis parameters for achieving efficient identification of gastrin-related molecules[3].
References:
[1] Matsumoto M, Park J, Yamada T. Gastrin receptor characterization: affinity cross-linking of the gastrin receptor on canine gastric parietal cells[J]. American Journal of Physiology-Gastrointestinal and Liver Physiology, 1987, 252(1): G143-G147.
[2] Moon H R, Mun S J, Kim T H, et al. Guidelines for manufacturing and application of organoids: liver[J]. International journal of stem cells, 2024, 17(2): 120-129.
[3] BARLOS K, GATOS D, KAPOLOS S, et al. Application of 2‐chlorotrityl resin in solid phase synthesis of (Leu15)‐gastrin I and unsulfated cholecystokinin octapeptide: Selective O‐deprotection of tyrosine[J]. International Journal of Peptide and Protein Research, 1991, 38(6): 555-561.