Ac-Leu-NHMe is an N-methylated derivative of leucine, commonly used as an amino acid protecting group[1-2]. The methylation modification of the amide nitrogen in Ac-Leu-NHMe effectively regulates the conformational flexibility of the peptide backbone and intermolecular interactions[3]. Ac-Leu-NHMe is commonly used to study the conformational effects and stability of peptides[4].
References:
[1] Boopathi S, Kolandaivel P. Molecular dynamics simulations and density functional theory studies of NALMA and NAGMA dipeptides. J Biomol Struct Dyn. 2013;31(2):158-73.
[2] Perticaroli S, Russo D, Paolantoni M, et al. Painting biological low-frequency vibrational modes from small peptides to proteins. Phys Chem Chem Phys. 2015 May 7;17(17):11423-31.
[3] Lupi L, Bracco B, Sassi P, et al. Hydration Dynamics of Model Peptides with Different Hydrophobic Character. Life (Basel). 2022 Apr 12;12(4):572.
[4] Johnson ME, Malardier-Jugroot C, Head-Gordon T. Effects of co-solvents on peptide hydration water structure and dynamics. Phys Chem Chem Phys. 2010 Jan 14;12(2):393-405.