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(+)-Sparteine Catalog No.GC34959

Size Price Stock Qty
10mM*1mL in Water
$52.00
In stock
100mg
$46.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 492-08-0 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES [H][C@]12CCCCN1C[C@H]3C[C@@H]2CN4CCCC[C@@]34[H]
Formula C15H26N2 M.Wt 234.38
Solubility H2O: 2.86 mg/mL (12.20 mM) Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

(+)-Sparteine is a natural alkaloid acting as a ganglionic blocking agent. (+)-Sparteine competitively blocks nicotinic ACh receptor in the neurons.

(+)-Sparteine (2 μM) reduces the ACh-induced current caused by activation of nicotinic AChRs in a voltage-independent manner. (+)-Sparteine (5, 10 μM) reduces the amplitude of the excitatory postsynaptic current (EPSC) and the time constant of the EPSC decay[1].

References:
[1]. Voitenko S, et al. Effect of (+)-sparteine on nicotinic acetylcholine receptors in the neurons of rat superior cervical ganglion. Mol Pharmacol. 1991 Aug;40(2):180-5.