Cyclooctyne-O-NHS ester is a derivative of Cyclooctyne, causes severe damage of HEK293 cells, and is used as an ADC cytotoxin[1].
[1]. Vogel K, et al. DNA-modification of eukaryotic cells. Small. 2013 Jan 28;9(2):255-62.
Cyclooctyne-O-NHS ester
Catalog No.: GC38016Purity:>98.00%
Cyclooctyne-O-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1425803-45-7
10 mgIn Stock
$360.00
1
100 mgIn Stock
$675.00
1
500 mgIn Stock
$1,620.00
1
1 gIn Stock
$2,340.00
1
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 10 mg | $360.00 | In Stock | 1 | |
| 100 mg | $675.00 | In Stock | 1 | |
| 500 mg | $1,620.00 | In Stock | 1 | |
| 1 g | $2,340.00 | In Stock | 1 |
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Nature641, 529–536 (2025)
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Cell187(9):2288-2304 (2024)
Cell183(7):1867-1883 (2020)
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Science387(6739) (2025)
Science387(6734) (2025)
Cell Research35, 97–116 (2025)
Cell Research34, 683–706 (2024)
Cell Research33, 273–287 (2023)
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Cell Research33, 904–922 (2023)
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Description
Product Documents
Purity:>98.00%Appearance:A solid
Chemical Properties
CAS No.
1425803-45-7
SMILES
O=C(ON1C(CCC1=O)=O)COC2C#CCCCCC2
Molecular Formula
C14H17NO5
Molecular Weight
279.29
Solubility
DMSO: 125 mg/mL (447.56 mM)
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility
g/mol
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