GLPBio

Glucokinase

Glucokinase phosphorylates glucose to produce glucose-6-phosphate during the initial step of glycogenesis. Pancreatic glucokinase regulates insulin secretion. Hepatic glucokinase facilitates the uptake and conversion of glucose.

Products Related to Glucokinase(17)

  • GC13124 structure
    GC13124LY2608204
    CAS: 1234703-40-2
    Purity: >98.00%

    LY2608204 (LY2608204) is a activator of glucokinase (GK) with EC50 of 42 nM.

  • GC18214 structure
    GC18214AM2394
    CAS: 1442684-77-6
    Purity: >99.00%

    A glucokinase activator

  • GC19029 structure
    GC19029AMG-3969
    CAS: 1361224-53-4
    Purity: >99.50%

    AMG-3969 is a potent glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor with an IC50 of 4 nM.

  • GC31514 structure
    GC31514PF-04991532
    CAS: 1215197-37-7
    Purity: >98%

    PF-04991532 is a potent, hepatoselective glucokinase activator with EC50s of 80 and 100 nM in human and rat, respectively.

  • GC31618 structure
    GC31618PSN-GK1
    CAS: 745051-61-0
    Purity: >98%

    PSN-GK1 is a potent glucokinase activator with an EC50 of 0.13 μM.

  • GC33765 structure
    GC33765Palmitelaidic Acid (9-trans-Hexadecenoic acid)
    CAS: 10030-73-6
    Purity: >98.00%

    Palmitelaidic Acid (9-trans-Hexadecenoic acid) is a trans isomer of palmitoleic acid and dietary fatty acid that has been found in dairy fat products and various partially hydrogenated oils.

  • GC36881 structure
    GC36881PF-04937319
    CAS: 1245603-92-2
    Purity: >99.50%

    PF-04937319 is a glucokinase activator (GKA) with EC50 value of 154.4 ?μM, one of the most promising strategies for the treatment of type 2 diabetes mellitus.

  • GC37546 structure
    GC37546Ro 28-1675
    CAS: 300353-13-3
    Purity: >99.50%

    Ro 28-1675 is a potent allosteric glucokinase (GK) activator with an EC50 of 54 nM.

  • GC38784 structure
    GC38784GKA50
    CAS: 851884-87-2
    Purity: >98%

    GKA50 is a potent glucokinase activator (EC50=33 nM at 5 mM glucose).

  • GC44210 structure
    GC44210MK-0941
    CAS: 1137916-97-2
    Purity: >98.50%

    MK-0941 is a glucokinase activator with EC50 values of 0.24 and 0.065 μM at low (2.5 mM) and high (10 mM) concentrations of glucose, respectively.

  • GC61749 structure
    GC61749GKA50 quarterhydrate
    Purity: >98%

    GKA50 quarterhydrate is a potent glucokinase activator (EC50=33 nM at 5 mM glucose) and stimulates insulin release from mouse islets of Langerhans.

  • GC62846 structure
    GC62846AR453588
    CAS: 1065609-00-8
    Purity: >99.50%

    AR453588 is a potent and orally bioavailable anti-diabetic glucokinase activator, with an EC50 of 42 nM.

  • GC66015 structure
    GC66015IHVR-11029
    CAS: 1383152-30-4
    Purity: >99.00%

    IHVR-11029 is a small molecule inhibitor of ER α-glucosidases, with an EC50 of 0.09 μM.

  • GC67901 structure
    GC67901Glucokinase activator 3
    CAS: 1001417-92-0
    Purity: >98%
  • GC68003 structure
    GC68003Cadisegliatin
    CAS: 859525-02-3
    Purity: >98%
  • GC68783 structure
    GC68783BMS-820132
    CAS: 1001419-18-6
    Purity: >99.00%

    BMS-820132 is an orally effective, partial glucokinase activator with an AC50 of 29 nM. It can lower glucose levels in normal rat oral glucose tolerance test (OGTT) models but does not reduce glucose levels in Zucker diabetic fatty (ZDF) rats. BMS-820132 has pharmacological toxicity secondary to potent GK activation.

  • GC70590 structure
    GC70590AMG-1694
    CAS: 1361217-07-3

    AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity.