GluR

mGluR5 receptor positive allosteric modulator, potent and selective

IEM 1754 dihydrobroMide, a dicationic adamantane derivative, is a potent blocker of open channels of native ionotropic glutamate receptors including quisqualate-sensitive receptors in insect muscles, NMDAR in cultured rat cortical neurons, and AMPAR in freshly isolated hippocampal cells.

NMDA receptor antagonist

Positive allosteric modulator(PAM) of mGlu4

MGlu4 receptor allosteric modulator

Positive allosteric mGluR-4 modulator

NMDA (N-Methyl-D-aspartic acid) is a specific agonist forNMDA (N-Methyl-D-aspartic acid)receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor.

Latrepirdine is a neuroactive compound with antagonist activity at histaminergic, α-adrenergic, and serotonergic receptors.

EAA receptor agonist

negative allosteric modulator of the mGlu5 receptor

group III metabotropic glutamate receptor agonist

Selective mGlu1 receptor non-competitive antagonist

negative allosteric modulator of group II mGlu receptors

positive allosteric modulator of mGlu5 receptors

positive allosteric modulator of the mGlu5 receptor

SIB 1893 is a racemic compound of (E)-SIB-1893 and (Z)-SIB-1893 isomers.

LY 354740 (LY354740) is a highly potent and selective group II (mGlu2/3) receptor agonist with IC50s of 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively.

Group I mGlu receptor antagonist

group II mGlu receptor agonist

mGlu1 receptor antagonist

mGlu5 antagonist

DFB (DFB) is a selective positive allosteric modulator of mGluR5.

amino acid that occurs naturally in the CNS

AMN 082 dihydrochloride, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain.