GLPBio

Glycohyocholic Acid-d4

Catalog No.: GC49006Purity:>99.00%Synonyms: GHCA-d4, Glycine Hyocholate-d4, Glycohyocholate-d4
COASDSData Sheet
An internal standard for the quantification of glycohyocholic acid

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Glycohyocholic Acid-d4
Cas No.: 32747-08-3
1 mgIn Stock
$374.00
1
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Description

Glycohyocholic Acid-d4 (GHCA-d4) is intended for use as an internal standard for the quantification of GHCA by GC- or LC-MS. GHCA is a glycine-conjugated form of the primary bile acid hyocholic acid .1 GHCA is upregulated 6.6-fold in the serum of patients with cirrhosis induced by hepatitis C virus (HCV) compared to healthy controls.2 Plasma levels of GHCA increase in patients who are no longer diabetic following gastric bypass surgery.3

1.Guo, L., Milburn, M.V., Ryals, J.A., et al.Plasma metabolomic profiles enhance precision medicine for volunteers of normal healthProc. Nat. Acad. Sci. USA112(35)E4901-E4910(2015) 2.Fitian, A.I., Nelson, D.R., Liu, C., et al.Integrated metabolomic profiling of hepatocellular carcinoma in hepatitis C cirrhosis through GC/MS and UPLC/MS-MSLiver Int.34(9)1428-1444(2014) 3.Yu, H., Ni, Y., Bao, Y., et al.Chenodeoxycholic acid as a potential prognostic marker for Roux-en-Y gastric bypass in Chinese obese patientsJ. Clin. Endocrinol. Metab.100(11)4222-4230(2015)

Product Documents

Purity:>99.00%Appearance:A crystalline solid
COASDSData Sheet

Chemical Properties

CAS No.
32747-08-3
Synonyms
GHCA-d4, Glycine Hyocholate-d4, Glycohyocholate-d4
SMILES
O[C@@H]1C([2H])([2H])C[C@@]2(C)[C@@]([C@@H](O)[C@@H](O)[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCC(NCC(O)=O)=O)([H])C1([2H])[2H]
Molecular Formula
C26H39D4NO6
Molecular Weight
469.7
Solubility
DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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