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Halofenozide

Catalog No.GC70382 Copy One-Click Copy Product Info

Halofenozide (RH-0345) is an ecdysteroid agonist.

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Halofenozide Chemical Structure

Cas No.: 112226-61-6

Size Price Stock Qty
10mM (in 1mL DMSO)
$59.00
In stock
1 mg
$45.00
In stock
5 mg
$81.00
In stock
10 mg
$108.00
In stock
25 mg
$189.00
In stock
50 mg
$279.00
In stock
100 mg
$391.00
In stock

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Sample solution is provided at 25 µL, 10mM.



Description of Halofenozide

Halofenozide (RH-0345) is an ecdysteroid agonist. RH-0345 belongs to a new group of insect growth regulators (IGRs) with a benzoylhydrazine structure that mimic the action of the natural insect molting hormone 20-hydroxyecdysone.

Halofenozide (RH-0345) reduces both growth and development of oocytes in vitro[1].

After topical application of Halofenozide (RH-0345; 5 and 10 μg) on adult females, the highest dose (10 μg) reduces significantly the reproductive parameters scored: namely the oviposition period, the fecundity and the egg viability[1].
Halofenozide at the two doses tested (5 and 10 μg) causes smaller eggs with a decrease in length, width and volume[1].

References:
[1]. Faïza Taïbi, et al. Effect of ecdysone agonist RH-0345 on reproduction of mealworm, Tenebrio molitor. Comp Biochem Physiol C Toxicol Pharmacol. 2003 Jul;135C(3):257-67.

Chemical Properties of Halofenozide

Cas No. 112226-61-6 SDF
Formula C18H19ClN2O2 M.Wt 330.81
Solubility DMSO : 125 mg/mL (377.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Halofenozide

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 3.0229 mL 15.1144 mL 30.2288 mL
5 mM 604.6 μL 3.0229 mL 6.0458 mL
10 mM 302.3 μL 1.5114 mL 3.0229 mL
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In vivo Formulation Calculator (Clear solution) of Halofenozide

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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