Hepatitis

Akt1, 2, and 3 are serine/threonine protein kinases in the phosphatidylinositol 3 (PI3)-kinase signalling pathway that play a critical role in the regulation of cell proliferation and survival.

Sulochrin is a fungal metabolite produced by A.

PHYSALIEN is a lipophilic carotenoid compound.

5,7-Dihydroxy-4-methylcoumarin is a coumarin derivative from Mexican tarragon. 5,7-Dihydroxy-4-methylcoumarin possesses antifungal and antibacterial activities .

2'-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication (IC50 = 0.3 μM in Huh-7 human hepatoma cells) that is not cytotoxic at concentrations up to 100 μM.

C22 Sphingomyelin is a naturally occurring form of sphingomyelin.

CAY10704 is a potent inhibitor of hepatitis C virus (HCV) infection (EC50 = 17 nM) that displays low cytotoxicity of virally-infected human hepatoma Huh7.5.1 cells (CC50 = 21.3 μM).

Gallotannin (Tannic acid) is a natural polyphenolic compound that has been found in various plants and has antioxidant, anti-inflammatory, anti-angiogenic, antiviral and anti-tumor biological activities. Gallotannin inhibits the activity of DNA polymerase α, β and κ with IC 50 values of 13, 130 and 30nM, respectively .

KIN1400 is a small molecule activator of the RIG-1-like receptor (RLR) pathway that has antiviral activity.

A JAK2 inhibitor

Simeprevir (TMC435; TMC435350) sodium is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM.

Tenofovir diphosphate is an inhibitor of HIV reverse transcriptase (Kis = 0.022 and 1.55 μM for RNA and DNA, respectively) and hepatitis B virus (HBV) polymerase (Ki = 0.18 μM).

Toll-Like Receptor 7 Ligand II (CL-087) is a potent, oral actively TLR7 agonist.

YM-53601 is a squalene synthase inhibitor (IC50s = 79 and 90 nM in HepG2 cells and rat liver microsomes, respectively).

An internal standard for the quantification of daclatasvir

A fungal metabolite with antiviral and anticancer activities

A mycotoxin with antiviral, insecticidal, and phytotoxic activities

A halogenated form of lauric acid

A quinolone alkaloid with diverse biological activities

A heterocyclic building block

A heterocyclic building block

An internal standard for the quantification of abacavir

An internal standard for the quantification of adefovir