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HIOC

Catalog No.GC50660

HIOC is a potent and selective activator of TrkB (tropomyosin related kinase B) receptor.

Products are for research use only. Not for human use. We do not sell to patients.

HIOC Chemical Structure

Cas No.: 314054-36-9

Size Price Stock Qty
10mg
$232.00
In stock
50mg
$985.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Selective TrkB receptor agonist. Protects neurons from excitotoxicity. Protects retinas from light-induced retinal degeneration (LIRD) in vivo. Blood brain barrier and blood-retinal barrier penetrant.

Chemical Properties

Cas No. 314054-36-9 SDF
Canonical SMILES OC1=CC=C2NC=C(C2=C1)CCNC(C3CCCNC3=O)=O
Formula C16H19N3O3 M.Wt 301.34
Solubility DMSO|30.13|100| Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 3.3185 mL 16.5926 mL 33.1851 mL
5 mM 0.6637 mL 3.3185 mL 6.637 mL
10 mM 0.3319 mL 1.6593 mL 3.3185 mL
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In vivo Formulation Calculator (Clear solution)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Reviews

Review for HIOC

Average Rating: 5 ★★★★★ (Based on Reviews and 38 reference(s) in Google Scholar.)

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