GLPBio

Hydrocortisone Aceponate

Catalog No.: GC52043Purity:>98.00%Synonyms: Hydrocortisone 17-Propionate 21-Acetate
Hydrocortisone aceponate (Hydrocortisone 17-propionate 21-acetate) is a potent topical glucocorticoid.

Products are for research use only. Not for human use. We do not sell to patients.


Hydrocortisone Aceponate
Cas No.: 74050-20-7
5 mgIn Stock
$43.00
1
10 mgIn Stock
$82.00
1
50 mgIn Stock
$260.00
1
100 mgIn Stock
$426.00
1

Citations

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    Nature
    641, 529–536 (2025)
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    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    388(6745) (2025)
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    35, 97–116 (2025)
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    34, 683–706 (2024)
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    31, 1291–1307 (2021)

Description

Hydrocortisone aceponate is a corticosteroid.1,2 Topical application of hydrocortisone aceponate (0.0584%) reduces lesion size and pruritis in cats with allergic dermatitis.1 It also induces remission and increases time to relapse in dogs with spontaneous atopic dermatitis.2 Formulations containing hydrocortisone aceponate have been used in the treatment of veterinary dermatoses.

1.Schmidt, V., Buckley, L.M., McEwan, N.A., et al.Efficacy of a 0.0584% hydrocortisone aceponate spray in presumed feline allergic dermatitis: An open label pilot studyVet. Dermatol.23(1)11-16(2012) 2.LourenÇo, A.M., Schmidt, V., Braz, B.S., et al.Efficacy of proactive long-term maintenance therapy of canine atopic dermatitis with 0.0584% hydrocortisone aceponate spray: A double-blind placebo controlled pilot studyVet. Dermatol.27(2)88e25-92e25(2016)

Product Documents

Purity:>98.00%Appearance:A solid

Chemical Properties

CAS No.
74050-20-7
Synonyms
Hydrocortisone 17-Propionate 21-Acetate
SMILES
C[C@@]12[C@](C(COC(C)=O)=O)(OC(CC)=O)CC[C@@]1([H])[C@@]3([H])[C@]([C@@]4(C(CC3)=CC(CC4)=O)C)([H])[C@H](C2)O
Molecular Formula
C26H36O7
Molecular Weight
460.6
Solubility
DMF: 3 mg/ml,DMSO: 10 mg/ml,Ethanol: 10 mg/ml,PBS (pH 7.2): insol
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

Reviews

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