I-138
Catalog No.: GC69249Purity:>98%
I-138 is an orally effective compound structurally related to ML323. I-138 and ML323 are potent USP1-UAF1 reversible inhibitors. I-138 displays synergistic binding with ubiquitin and mutually exclusive binding with ML323. I-138 induces mono-ubiquitination of FANCD2 and PCNA in MDA-MB-436 cells, increasing mono-ubiquitination of PCNA and FANCD2 in HAP-1 USP1 WT cells. I-138 eliminates self-cleavage of USP1 in cells.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2098211-50-6
10mM (in 1mL DMSO)In Stock
$386.00
1
1mgIn Stock
$225.00
1
5mgIn Stock
$351.00
1
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 10mM (in 1mL DMSO) | $386.00 | In Stock | 1 | |
| 1mg | $225.00 | In Stock | 1 | |
| 5mg | $351.00 | In Stock | 1 |
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Citations
No citations are currently available for this product. Below are selected publications citing GlpBio products.
Nature641, 529–536 (2025)
Nature628, 630–638 (2024)
Nature632, 686–694 (2024)
Nature618, 1017–1023 (2023)
Nature610, 366–372 (2022)
Cell187(9):2288-2304 (2024)
Cell183(7):1867-1883 (2020)
Science388(6745) (2025)
Science387(6739) (2025)
Science387(6734) (2025)
Cell Research35, 97–116 (2025)
Cell Research34, 683–706 (2024)
Cell Research33, 273–287 (2023)
Cell Research33, 546–561 (2023)
Cell Research33, 904–922 (2023)
Cell Research31, 1291–1307 (2021)
Chemical Properties
CAS No.
2098211-50-6
Molecular Formula
C26H23F3N6O
Molecular Weight
492.5
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility
g/mol
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