I-SAP is a high affinity TP receptor antagonist. At physiologic pH, I-SAP produces platelet shape change, but not aggregation, with an EC50 value of 9.7 nM. I-SAP binds to human platelets with the maximum binding obtained between pH 6.5 and pH 7.4. In washed human platelets, the Kd for I-SAP is 468 pM at pH 7.4 and 490 pM at pH 6.5.
I-SAP
Catalog No.: GC43910Purity:>98.00%Synonyms: Iodophenyl sulfonyl amino pinane Thromboxane A2, Iodophenyl sulfonyl amino pinane TXA2
I-SAP is a high affinity TP receptor antagonist.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 133538-58-6
100μgIn Stock
$112.00
1
500μgIn Stock
$499.00
1
1mgIn Stock
$886.00
1
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 100μg | $112.00 | In Stock | 1 | |
| 500μg | $499.00 | In Stock | 1 | |
| 1mg | $886.00 | In Stock | 1 |
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Citations
No citations are currently available for this product. Below are selected publications citing GlpBio products.
Nature641, 529–536 (2025)
Nature628, 630–638 (2024)
Nature632, 686–694 (2024)
Nature618, 1017–1023 (2023)
Nature610, 366–372 (2022)
Cell187(9):2288-2304 (2024)
Cell183(7):1867-1883 (2020)
Science388(6745) (2025)
Science387(6739) (2025)
Science387(6734) (2025)
Cell Research35, 97–116 (2025)
Cell Research34, 683–706 (2024)
Cell Research33, 273–287 (2023)
Cell Research33, 546–561 (2023)
Cell Research33, 904–922 (2023)
Cell Research31, 1291–1307 (2021)
Description
Product Documents
Purity:>98.00%Appearance:A solution in ethanol
Chemical Properties
CAS No.
133538-58-6
Synonyms
Iodophenyl sulfonyl amino pinane Thromboxane A2, Iodophenyl sulfonyl amino pinane TXA2
SMILES
CC1(C)[C@@H]2[C@H](C/C=C\CCCC(O)=O)[C@@H](N([H])S(C3=CC=C(I)C=C3)(=O)=O)C[C@H]1C2
Molecular Formula
C22H30INO4S
Molecular Weight
531.4
Solubility
DMF: >50 mg/ml (from Pinane TXA2),DMSO: >25 mg/ml (from Pinane TXA2),Ethanol: >100 mg/ml (from Pinane TXA2),PBS pH 7.2: >100 µ g/ml (from Pinane TXA2)
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility
g/mol
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