Cardiovascular
Cardiovascular
The cardiovascular system consists of the heart, blood and blood vessels. These organs form the 3 major closed circulation systems in the body, i.e., the pulmonary, coronary and systemic circulations. Cardiovascular disease includes heart disease, vascular diseases of the brain and kidney, and peripheral arterial diseases. Cardiovascular disease is the leading cause of death globally. Studies on cardiovascular regulation are important to provide a better understanding of this group of diseases and to help improve the corresponding treatment.
Targets for Cardiovascular
Products for Cardiovascular
- Cat.No. Product Name Information
- GC45208 α-hydroxy Metoprolol α-hydroxy Metoprolol is an active metabolite of the β1-adrenergic receptor blocker metoprolol.
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GC48283
α-Linolenic Acid-d14
ALAd14
An internal standard for the quantification of αLinolenic acid -
GC45602
α-Linolenic Acid-d5 MaxSpec• Standard
ALA-d5, C18:3 (9Z,12Z,15Z)-d5, C18:3 n-3-d5
- GC49467 β-Aescin A triterpenoid saponin with diverse biological activities
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GC49890
β-Glycerophosphate-d5 (sodium salt hydrate)
Glycerol 2-Phosphate-d5
An internal standard for the quantification of β-glycerophosphate - GC40105 βARK1 Inhibitor βARK1 Inhibitor (methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate) is a GRK2 (β-ARK1) inhibitor.
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GC52400
γ-Glu-Ala (trifluoroacetate salt)
γ-Glutamylalanine, γ-L-Glutamyl-L-alanine
A dipeptide -
GC52404
γ-Glu-Phe (trifluoroacetate salt)
γ-Glutamylphenylalanine
A dipeptide with metabolism-altering activity - GC41393 ω-3 Arachidonic Acid methyl ester ω-3 Fatty acids, represented primarily by docosahexaenoic acid, eicosapentaenoic acid, and α-linoleate, are essential dietary nutrients required for normal growth and development.
- GC41661 (±)-4-hydroxy Propranolol β-D-Glucuronide (±)-4-hydroxy Propranolol β-D-glucuronide is a metabolite of (±)-4-hydroxy propranolol, which is a metabolite of propranolol.
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GC46273
(±)-Atenolol-d7
(R,S)-Atenolol-d7, Duraatenol, ICI 66082
An internal standard for the quantification of (±)-atenolol - GC46289 (±)-Felodipine-d5 An internal standard for the quantification of (±)-felodipine
- GC46307 (±)-Propranolol-d7 An internal standard for the quantification of propranolol
- GC40229 (±)-Warfarin-d5 (±)-Warfarin-d5 is intended for use as an internal standard for the quantification of warfarin by GC- or LC-MS.
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GC40386
(±)11(12)-EpETE
(±)11,12-EEQ, (±)11,12-Epoxyeicosatetraenoic Acid
Eicosapentaenoic acid is converted to epoxyeicosatetraenoic acids (EpETE) by several cytochrome P450 isoforms. -
GC40467
(±)11-HETE
(±)11-Hydroxyeicosatetraenoic Acid
(±)11-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. - GC41649 (±)13-HODE cholesteryl ester (±)13-HODE cholesteryl ester was originally extracted from atherosclerotic lesions and shown to be produced by Cu2+-catalyzed oxidation of LDL.
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GC40430
(±)14(15)-EET
(±)14,15-EET, (±)14,15-EpETrE
(±)14(15)-EET is biosynthesized in rat and rabbit liver microsomes by CYP450.
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GC41651
(±)14(15)-EET-SI
14,15-EpETrE-SI, 14(15)-EET-SI, 14(15)EETsulfonimide
Arachidonic acid is metabolized in the vascular endothelium to epoxytrienoic acids (EETs or EpETrEs) by cytochrome P450 enzymes. -
GC40434
(±)16-HETE
(±)16-Hydroxyeicosatetraenoic Acid
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. -
GC41288
(±)17(18)-EpETE-Ethanolamide
17,18-EEQ-EA, (±)17,18-EEQ-Ethanolamide, (±)17(18)-EpETE-EA, 17,18-epoxy-Eicosatetraenoic Acid Ethanolamide
(±)17(18)-EpETE-Ethanolamide is an ω-3 endocannabinoid epoxide. - GC40362 (±)18-HEPE (±)18-HEPE is produced by non-enzymatic oxidation of EPA.
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GC40436
(±)18-HETE
(±)18-Hydroxyeicosatetraenoic Acid
(±)18-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid. -
GC41655
(±)19(20)-EDP Ethanolamide
19,20-DHEA epoxide, 19,20-epoxy Docosapentaenoic Acid Ethanolamide, 19,20-EDP-EA, 19,20-EDP epoxide
(±)19(20)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 108 and 280 nM for CB1 and CB2, respectively). -
GC40437
(±)5(6)-DiHET lactone
(±)5,6DiHETrE lactone
5,6-DiHET lactone is a lactonized form of 5,6-EET and 5,6-DiHET. -
GC40438
(±)5(6)-EET
(±)5,6EpETrE
5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. -
GC40421
(±)8(9)-EE-14(Z)-E
(±)8,9-Epoxyeicosa-14(Z)-enoic Acid
(±)14(15)-EE-8(Z)-E is a potent vasodilator in bovine coronary arteries. -
GC40443
(±)9-HETE
(±)9-Hydroxyeicosatetraenoic Acid
(±)9-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. -
GC40541
(±)9-HODE
(±)9-HODE is one of the two racemic monohydroxy fatty acids resulting from the non-enzymatic oxidation of linoleic acid.
- GC41666 (±)9-HODE cholesteryl ester (±)9-HODE cholesteryl ester was originally extracted from atherosclerotic lesions and shown to be produced by Cu2+-catalyzed oxidation of LDL.
- GC40356 (±)9-HpODE (±)9-HpODE is a racemic mixture of the fatty acid hydroperoxide product (9(S)-HpODE) formed from lipoxygenase action on linoleic acid.
- GC49690 (3R,5R)-Rosuvastatin (calcium salt) A potential impurity found in bulk preparations of rosuvastatin
- GC41694 (3S)-hydroxy Quinidine (3S)-hydroxy Quinidine is an active quinidine metabolite.
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GC48508
(4-Carboxybutyl-d4)triphenylphosphonium (bromide)
TPP-d4, 5-Triphenylphosphoniovaleric Acid-d4
An internal standard for the quantification of (4-carboxybutyl)triphenylphosphonium -
GC40444
(5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic Acid
HETE Analog 1, Hydroxyeicosatetraenoic Acid Analog 1
(5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic acid is a stable isomer of 15(S)-HETE, a major arachidonic acid metabolite from the 15-lipoxygenase pathway. -
GC49003
(E)-Ajoene
NSC 614554
A disulfide with diverse biological activities - GC46336 (E)-Guggulsterone A farnesoid X receptor antagonist
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GC40552
(R)-Acenocoumarol
(R)Acenocoumarin, (R)Nicoumalone
Acenocoumarol is a short-lived oral anti-coagulant, which, like warfarin, functions by inhibiting vitamin K epoxide reductase. - GC41722 (R,S)-Carvedilol Glucuronide (R,S)-Carvedilol glucuronide is a racemic mixture of the carvedilol metabolites (R)-carvedilol glucuronide and (S)-carvedilol glucuronide.
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GC40553
(S)-Acenocoumarol
(S)Acenocoumarin, (S)Nicoumalone
Acenocoumarol is a short-lived oral anti-coagulant, which, like warfarin, functions by inhibiting vitamin K epoxide reductase. -
GC48719
(S)-Canadine
(–)-Canadine, (S)-Tetrahydroberberine
(S)-Canadine is an alkaloid and intermediate in the biosynthesis of berberine with insecticidal activity. - GC49034 1(R)-(Trifluoromethyl)oleyl alcohol An oleic acid analog
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GC41837
1,3,7-Trimethyluric Acid
8-oxo Caffeine, NSC 11259
1,3,7-Trimethyluric acid is a methyl derivative of uric acid and a product of C-8 oxidation of caffeine by cytochrome P450 enzymes.
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GC46387
1,3,7-Trimethyluric Acid-d9
TMU-d9, 8-oxo Caffeine-d9
An internal standard for the quantification of 1,3,7-trimethyluric acid -
GC41846
1,3-Dioctanoyl-2-Oleoyl-rac-glycerol
1,3-Caprylin-2-Olein, 1,3-Dicapryloyl-2-Oleoyl Glycerol, TG(8:0/18:1/8:0), 8:0/18:1/8:0-TG
1,3-Dioctanoyl-2-oleoyl-rac-glycerol is a triacylglycerol that contains octanoic acid at the sn-1 and sn-3 positions and oleic acid at the sn-2 position. -
GC49346
1-(3-Chlorophenyl)biguanide (hydrochloride)
m-Chlorophenylbiguanide hydrochloride, meta-Chlorophenylbiguanide, m-CPBG, meta-CPBG
A 5-HT3 receptor agonist -
GC18235
1-O-Hexadecyl-sn-glycerol
α-Chimyl Alcohol, (S)-(+)-Chimyl Alcohol
1-O-Hexadecyl-sn-glycerol is a bioactive alkyl glyceryl ether.
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GC42008
1-Octadecyl Lysophosphatidic Acid
1Octadecyl LPA
1-Octadecyl lysophosphatidic acid (1-octadecyl LPA) is a LPA analog containing stearic acid at the sn-1 position. -
GC49071
1-Palmitoyl-d9 Lysophosphatidic Acid
1-Palmitoyl-d9 LPA
An internal standard for the quantification of 1-palmitoyl lysophosphatidic acid -
GC46496
1-Stearoyl-2-Arachidonoyl-d8-sn-glycero-3-PC
18:0/20:4-d8-PC, PC(18:0/20:4-d8), SAPCd8, 1-Stearoyl-2-Arachidonoyl-d8-sn-glycero-3-Phosphatidylcholine, 1-Stearoyl-2-Arachidonoyl-d8-sn-glycero-3-Phosphocholine
An internal standard for the quantification of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PC -
GC49733
1-Stearoyl-2-eicosapentaenoyl-sn-glycero-3-PC
1-Octadecanoyl-1-Eiocosapentaenoyl-sn-glycero-3-Phosphatidylcholine, 1-Octadecanoyl-1-Eiocosapentaenoyl-sn-glycero-3-Phosphocholine, PC(18:0/20:5), 18:0/20:5-PC
A phospholipid - GC49118 10-hydroxy Warfarin A metabolite of (R)-warfarin
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GC46408
11-dehydro Thromboxane B2-d4
11-dehydro TXB2-d4, 11keto TXB2d4
An internal standard for the quantification of 11dehydro thromboxane B2 -
GC18634
11-deoxy Prostaglandin E1
11deoxy PGE1
11-deoxy Prostaglandin E1 (11-deoxy PGE1) is a synthetic analog of PGE1. -
GC41401
11-deoxy Prostaglandin F1α
11deoxy PGF1α
11-deoxy PGF1α is a synthetic analog of PGF1α. -
GC41402
11-deoxy Prostaglandin F1β
9β,11deoxy PGF1α, 11deoxy PGF1β
11-deoxy PGF1β is a synthetic analog of PGF1β. -
GC18637
11β-Prostaglandin F2α
9α,11βPGF2α, 11βPGF2α, 11epi PGF2α
11β-Prostaglandin F2α (11β-PGF2α) is the primary plasma metabolite of PGD2 in vivo.
- GC41882 12(S)-HETrE 12(S)-HETrE is produced by 12-lipoxygenase oxidation of dihomo-γ-linolenic acid (DGLA).
- GC41893 13(R)-HODE cholesteryl ester 13(R)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions.
- GC41895 13(S)-HODE cholesteryl ester 13(S)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions.
- GC41897 13(S)-HOTrE 13(S)-HOTrE is the 15-lipoxygenase (15-LO) product of linolenic acid.
- GC40745 13,14-dehydro-15-cyclohexyl Carbaprostacyclin 13,14-dehydro-15-cyclohexyl Carbaprostacyclin is a chemically stable analog of PGI2.
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GC41433
13,14-dihydro Prostaglandin E1
PGE0, 13,14-dihydro PGE1
13,14-dihydro Prostaglandin E1 (13,14-dihydro PGE1) is a biologically active metabolite of PGE1 with comparable potency to the parent compound. -
GC40424
14,15-EE-5(Z)-E
14,15Epoxyeicosa5(Z)enoic Acid
Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity. -
GC40425
14,15-EE-8(Z)-E
14,15Epoxyeicosa8(Z)enoic Acid
Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity. -
GC46438
14S(15R)-EET
14S,15R-EpETrE
A cytochrome P450 metabolite of arachidonic acid -
GC41173
15(R)-Pinane Thromboxane A2
15-epi-Pinane Thromboxane A2, 15-iso-Pinane Thromboxane A2, 15(R)PTA2, 15-epi-PTA2, 15-iso-PTA2
15(R)-Pinane thromboxane A2 is the (R)-epimer of pinane thromboxane A2. -
GC41166
15(S)-15-methyl Prostaglandin D2
15(S)15methyl PGD2
15(S)-15-methyl Prostaglandin D2 (15(S)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2. -
GC41103
15-keto Prostaglandin A1
15keto PGA1
Prostaglandin A1 (PGA1) was first isolated as a dehydration product of the PGE1 compounds found in human semen. - GC41935 15-keto Treprostinil (sodium salt) 15-keto Treprostinil is an impurity found in treprostinil, which is a stable analog of prostaglandin I2 with a longer plasma half-life.
- GC40973 16(R)-Iloprost Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin.
- GC40974 16(S)-Iloprost Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin.
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GC41159
16,16-dimethyl Prostaglandin D2
16,16dimethyl PGD2
16,16-dimethyl PGD2 is a metabolically stable synthetic analog of PGD2. -
GC18777
16,16-dimethyl Prostaglandin E1
16,16dimethyl PGE1
16,16-dimethyl PGE1 is a metabolically stable synthetic analog of PGE1. -
GC46464
17R(18S)-EpETE
17R,18S-EEQ, 17R,18S-epoxy Eicosatetraenoic Acid
An EPA metabolite and activator of BKCa channels -
GC46474
18-Deoxyherboxidiene
RQN-18690A
A bacterial metabolite with antiangiogenic activity -
GC18635
18-hydroxy-11-deoxy Corticosterone
18-Hydroxydeoxycorticosterone, 18-OH-DOC
18-hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid secreted by the zona fasciculata of the adrenal gland. -
GC40457
19(R)-HETE
19(R)-Hydroxyeicosatetraenoic Acid
19-HETE is one of the major cytochrome P450 (CYP450) metabolites of arachidonic acid that is released from the kidney in response to angiotensin II. - GC40417 19-hydroxy Cholesterol 19-hydroxy Cholesterol is formed during metabolic oxidation of cholesterol.
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GC46475
19R(20S)-EpDPA
19R,20S-epoxy Docosapentaenoic Acid, 19R,20S-epoxy DPA, 19R,20S-EDP, 19R,20S-EpDPE
A DHA metabolite -
GC18748
1a,1b-dihomo Prostaglandin E1
1a,1bdihomo PGE1
Prostaglandin E1 (PGE1) is not a major naturally occurring PG, but is widely administered clinically for several indications including peripheral occlusive vascular disease, erectile dysfunction, and in neonatal cardiology. -
GC52122
2’-Deoxyadenosine-5’-diphosphate (sodium salt)
dADP, 2'-deoxy-ADP
A nucleotide diphosphate -
GC42065
2,3-dinor Thromboxane B1
2,3dinor TXB1
Thromboxane B2 (TXB2) is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2. -
GC49671
2,3-Oxidosqualene
(3R,S)-Oxidosqualene, Squalene 2,3-oxide
An intermediate in the biosynthesis of sterols - GC19560 2-(2-Phenylethyl)chromone 2-(2-Phenylethyl)chromone (Flidersiachromone) is one of 2-(2-phenylethyl)chromones that can be found in Chinese eaglewood from Aquilaria sinensis.
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GC42135
2-chloro Palmitic Acid
2-ClHA, 2-CLPA
2-chloro Palmitic Acid, an inflammatory lipid mediator, interferes with protein palmitoylation,induces ER-stress markers, reduced the ER ATP content, and activates transcription and secretion of IL-6 as well as IL-8.2-chloro Palmitic Acid disrupts the mitochondrial membrane potential and induces procaspase-3 and PARP cleavage.2-chloro Palmitic Acid can across blood-brain barrier (BBB) and compromises ER- and mitochondrial functions in the human brain endothelial cell line hCMEC/D3. -
GC40503
2-HOBA
2-(Aminomethyl)phenol, 2-Hydroxybenzylamine, NSC 127870
2-HOBA (2-HOBA) a selective dicarbonyl scavenger, is an antioxidant and scavanger of free radicals and isolevuglandins (IsoLGs). - GC42189 2-oxo Clopidogrel 2-oxo Clopidogrel is an intermediary metabolite of clopidogrel.
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GC41104
20-carboxy Arachidonic Acid
20carboxy AA, 20COOHAA
20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. -
GC41614
24-dehydro Cholesterol
Desmosterol
24-dehydro Cholesterol is a molecule similar to cholesterol. -
GC46243
24-dehydro Cholesterol-d6
Desmosterol-d6
An internal standard for the quantification of 24-dehydro cholesterol - GC46528 25-hydroxy Cholesterol-d6 An internal standard for the quantification of 25hydroxy cholesterol
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GC52324
3-(3-Hydroxyphenyl)propionic Acid sulfate
3-HPPA sulfate
A metabolite of certain phenols and glycosides -
GC40799
3-hydroxy-3-Methylglutaric anhydride
Dicrotalic anhydride, HMG anhydride
The enzyme 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase mediates the rate-limiting step in cholesterol synthesis, converting HMG-CoA to mevalonate. -
GC52048
3-hydroxy-4-Methoxyphenethylamine (hydrochloride)
4-O-methyl Dopamine, p-methoxy Dopamine, para-methoxy Dopamine, 4-methoxy-3-Hydroxyphenethylamine
3-hydroxy-4-Methoxyphenethylamine (hydrochloride) is a catecholamine compound that has an inhibitory effect on dihydropteridine reductase. - GC52149 306-O12B 306-O12B is an ionizable cationic lipid used to generate lipid nanoparticles (LNPs).
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GC42338
4-Aminobenzoic Acid hydrazide
4ABAH, Myeloperoxidase Inhibitor 1, NSC 640
4-Aminobenzoic Acid hydrazide is an irreversible MPO myeloperoxidase inhibitor with an IC50 of 0.3 μM. -
GC42405
4-hydroxy Atorvastatin (calcium salt)
p-hydroxy Atorvastatin, para-hydroxy Atorvastatin
4-hydroxy Atorvastatin is a metabolite of atorvastatin, an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias. -
GC18425
4-hydroxy Atorvastatin lactone
p-hydroxy Atorvastatin lactone, para-hydroxy Atorvastatin lactone
4-hydroxy Atorvastatin lactone is a metabolite of atorvastatin , an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias.
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GC42411
4-hydroxy Nonenal Alkyne
Click Tag 4HNE Alkyne
4-hydroxy Nonenal (4-HNE) is a major aldehyde produced during the lipid peroxidation of ω-6 polyunsaturated fatty acids, such as arachidonic acid and linoleic acid.