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Cardiovascular

Cardiovascular

Cardiovascular

The cardiovascular system consists of the heart, blood and blood vessels. These organs form the 3 major closed circulation systems in the body, i.e., the pulmonary, coronary and systemic circulations. Cardiovascular disease includes heart disease, vascular diseases of the brain and kidney, and peripheral arterial diseases. Cardiovascular disease is the leading cause of death globally. Studies on cardiovascular regulation are important to provide a better understanding of this group of diseases and to help improve the corresponding treatment.

Targets for  Cardiovascular

Products for  Cardiovascular

  1. Cat.No. Product Name Information
  2. GC45208 α-hydroxy Metoprolol α-hydroxy Metoprolol is an active metabolite of the β1-adrenergic receptor blocker metoprolol. α-hydroxy Metoprolol  Chemical Structure
  3. GC45602 α-Linolenic Acid-d5 MaxSpec• Standard   α-Linolenic Acid-d5 MaxSpec• Standard  Chemical Structure
  4. GC49467 β-Aescin A triterpenoid saponin with diverse biological activities β-Aescin  Chemical Structure
  5. GC40105 βARK1 Inhibitor βARK1 inhibitor is an inhibitor of G protein-coupled receptor kinase 2/β-adrenergic receptor kinase 1 (GRK2/βARK1; IC50 = 126 μM). βARK1 Inhibitor  Chemical Structure
  6. GC41393 ω-3 Arachidonic Acid methyl ester ω-3 Fatty acids, represented primarily by docosahexaenoic acid, eicosapentaenoic acid, and α-linoleate, are essential dietary nutrients required for normal growth and development. ω-3 Arachidonic Acid methyl ester  Chemical Structure
  7. GC41661 (±)-4-hydroxy Propranolol β-D-Glucuronide (±)-4-hydroxy Propranolol β-D-glucuronide is a metabolite of (±)-4-hydroxy propranolol, which is a metabolite of propranolol. (±)-4-hydroxy Propranolol β-D-Glucuronide  Chemical Structure
  8. GC40229 (±)-Warfarin-d5 (±)-Warfarin-d5 is intended for use as an internal standard for the quantification of warfarin by GC- or LC-MS. (±)-Warfarin-d5  Chemical Structure
  9. GC40386 (±)11(12)-EpETE Eicosapentaenoic acid is converted to epoxyeicosatetraenoic acids (EpETE) by several cytochrome P450 isoforms. (±)11(12)-EpETE  Chemical Structure
  10. GC40467 (±)11-HETE (±)11-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. (±)11-HETE  Chemical Structure
  11. GC41649 (±)13-HODE cholesteryl ester (±)13-HODE cholesteryl ester was originally extracted from atherosclerotic lesions and shown to be produced by Cu2+-catalyzed oxidation of LDL. (±)13-HODE cholesteryl ester  Chemical Structure
  12. GC40430 (±)14(15)-EET

    (±)14(15)-EET is biosynthesized in rat and rabbit liver microsomes by CYP450.

    (±)14(15)-EET  Chemical Structure
  13. GC41651 (±)14(15)-EET-SI Arachidonic acid is metabolized in the vascular endothelium to epoxytrienoic acids (EETs or EpETrEs) by cytochrome P450 enzymes. (±)14(15)-EET-SI  Chemical Structure
  14. GC40434 (±)16-HETE Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)16-HETE  Chemical Structure
  15. GC41288 (±)17(18)-EpETE-Ethanolamide (±)17(18)-EpETE-Ethanolamide is an ω-3 endocannabinoid epoxide. (±)17(18)-EpETE-Ethanolamide  Chemical Structure
  16. GC40362 (±)18-HEPE (±)18-HEPE is produced by non-enzymatic oxidation of EPA. (±)18-HEPE  Chemical Structure
  17. GC40436 (±)18-HETE (±)18-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid. (±)18-HETE  Chemical Structure
  18. GC41655 (±)19(20)-EDP Ethanolamide (±)19(20)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 108 and 280 nM for CB1 and CB2, respectively). (±)19(20)-EDP Ethanolamide  Chemical Structure
  19. GC40437 (±)5(6)-DiHET lactone 5,6-DiHET lactone is a lactonized form of 5,6-EET and 5,6-DiHET. (±)5(6)-DiHET lactone  Chemical Structure
  20. GC40438 (±)5(6)-EET 5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. (±)5(6)-EET  Chemical Structure
  21. GC40421 (±)8(9)-EE-14(Z)-E (±)14(15)-EE-8(Z)-E is a potent vasodilator in bovine coronary arteries. (±)8(9)-EE-14(Z)-E  Chemical Structure
  22. GC40443 (±)9-HETE (±)9-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. (±)9-HETE  Chemical Structure
  23. GC40541 (±)9-HODE

    (±)9-HODE is one of the two racemic monohydroxy fatty acids resulting from the non-enzymatic oxidation of linoleic acid.

    (±)9-HODE  Chemical Structure
  24. GC41666 (±)9-HODE cholesteryl ester (±)9-HODE cholesteryl ester was originally extracted from atherosclerotic lesions and shown to be produced by Cu2+-catalyzed oxidation of LDL. (±)9-HODE cholesteryl ester  Chemical Structure
  25. GC40356 (±)9-HpODE (±)9-HpODE is a racemic mixture of the fatty acid hydroperoxide product (9(S)-HpODE) formed from lipoxygenase action on linoleic acid. (±)9-HpODE  Chemical Structure
  26. GC49690 (3R,5R)-Rosuvastatin (calcium salt) A potential impurity found in bulk preparations of rosuvastatin (3R,5R)-Rosuvastatin (calcium salt)  Chemical Structure
  27. GC41694 (3S)-hydroxy Quinidine (3S)-hydroxy Quinidine is an active quinidine metabolite. (3S)-hydroxy Quinidine  Chemical Structure
  28. GC40444 (5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic Acid (5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic acid is a stable isomer of 15(S)-HETE, a major arachidonic acid metabolite from the 15-lipoxygenase pathway. (5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic Acid  Chemical Structure
  29. GA20031 (Arg⁶,β-cyclohexyl-Ala⁸,D-Tic¹⁶,Arg¹⁷,Cys¹⁸)-Atrial Natriuretic Factor (6-18) amide (mouse, rabbit, rat) The ANP antagonist A71915 inhibits ANP-induced cGMP stimulation. (Arg⁶,β-cyclohexyl-Ala⁸,D-Tic¹⁶,Arg¹⁷,Cys¹⁸)-Atrial Natriuretic Factor (6-18) amide (mouse, rabbit, rat)  Chemical Structure
  30. GC40552 (R)-Acenocoumarol Acenocoumarol is a short-lived oral anti-coagulant, which, like warfarin, functions by inhibiting vitamin K epoxide reductase. (R)-Acenocoumarol  Chemical Structure
  31. GC41722 (R,S)-Carvedilol Glucuronide (R,S)-Carvedilol glucuronide is a racemic mixture of the carvedilol metabolites (R)-carvedilol glucuronide and (S)-carvedilol glucuronide. (R,S)-Carvedilol Glucuronide  Chemical Structure
  32. GC40553 (S)-Acenocoumarol Acenocoumarol is a short-lived oral anti-coagulant, which, like warfarin, functions by inhibiting vitamin K epoxide reductase. (S)-Acenocoumarol  Chemical Structure
  33. GC41837 1,3,7-Trimethyluric Acid

    1,3,7-Trimethyluric acid is a methyl derivative of uric acid and a product of C-8 oxidation of caffeine by cytochrome P450 enzymes.

    1,3,7-Trimethyluric Acid  Chemical Structure
  34. GC41846 1,3-Dioctanoyl-2-Oleoyl-rac-glycerol 1,3-Dioctanoyl-2-oleoyl-rac-glycerol is a triacylglycerol that contains octanoic acid at the sn-1 and sn-3 positions and oleic acid at the sn-2 position. 1,3-Dioctanoyl-2-Oleoyl-rac-glycerol  Chemical Structure
  35. GC18235 1-O-Hexadecyl-sn-glycerol

    1-O-Hexadecyl-sn-glycerol is a bioactive alkyl glyceryl ether.

    1-O-Hexadecyl-sn-glycerol  Chemical Structure
  36. GC42008 1-Octadecyl Lysophosphatidic Acid 1-Octadecyl lysophosphatidic acid (1-octadecyl LPA) is a LPA analog containing stearic acid at the sn-1 position. 1-Octadecyl Lysophosphatidic Acid  Chemical Structure
  37. GC49733 1-Stearoyl-2-eicosapentaenoyl-sn-glycero-3-PC A phospholipid 1-Stearoyl-2-eicosapentaenoyl-sn-glycero-3-PC  Chemical Structure
  38. GC18634 11-deoxy Prostaglandin E1 11-deoxy Prostaglandin E1 (11-deoxy PGE1) is a synthetic analog of PGE1. 11-deoxy Prostaglandin E1  Chemical Structure
  39. GC41401 11-deoxy Prostaglandin F1α 11-deoxy PGF1α is a synthetic analog of PGF1α. 11-deoxy Prostaglandin F1α  Chemical Structure
  40. GC41402 11-deoxy Prostaglandin F1β 11-deoxy PGF1β is a synthetic analog of PGF1β. 11-deoxy Prostaglandin F1β  Chemical Structure
  41. GC18637 11β-Prostaglandin F2α

    11β-Prostaglandin F2α (11β-PGF2α) is the primary plasma metabolite of PGD2 in vivo.

    11β-Prostaglandin F2α  Chemical Structure
  42. GC41882 12(S)-HETrE 12(S)-HETrE is produced by 12-lipoxygenase oxidation of dihomo-γ-linolenic acid (DGLA). 12(S)-HETrE  Chemical Structure
  43. GC41893 13(R)-HODE cholesteryl ester 13(R)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions. 13(R)-HODE cholesteryl ester  Chemical Structure
  44. GC41895 13(S)-HODE cholesteryl ester 13(S)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions. 13(S)-HODE cholesteryl ester  Chemical Structure
  45. GC41897 13(S)-HOTrE 13(S)-HOTrE is the 15-lipoxygenase (15-LO) product of linolenic acid. 13(S)-HOTrE  Chemical Structure
  46. GC40745 13,14-dehydro-15-cyclohexyl Carbaprostacyclin 13,14-dehydro-15-cyclohexyl Carbaprostacyclin is a chemically stable analog of PGI2. 13,14-dehydro-15-cyclohexyl Carbaprostacyclin  Chemical Structure
  47. GC41433 13,14-dihydro Prostaglandin E1 13,14-dihydro Prostaglandin E1 (13,14-dihydro PGE1) is a biologically active metabolite of PGE1 with comparable potency to the parent compound. 13,14-dihydro Prostaglandin E1  Chemical Structure
  48. GC40424 14,15-EE-5(Z)-E Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity. 14,15-EE-5(Z)-E  Chemical Structure
  49. GC40425 14,15-EE-8(Z)-E Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity. 14,15-EE-8(Z)-E  Chemical Structure
  50. GC41173 15(R)-Pinane Thromboxane A2 15(R)-Pinane thromboxane A2 is the (R)-epimer of pinane thromboxane A2. 15(R)-Pinane Thromboxane A2  Chemical Structure
  51. GC41166 15(S)-15-methyl Prostaglandin D2 15(S)-15-methyl Prostaglandin D2 (15(S)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2. 15(S)-15-methyl Prostaglandin D2  Chemical Structure
  52. GC41103 15-keto Prostaglandin A1 Prostaglandin A1 (PGA1) was first isolated as a dehydration product of the PGE1 compounds found in human semen. 15-keto Prostaglandin A1  Chemical Structure
  53. GC41935 15-keto Treprostinil (sodium salt) 15-keto Treprostinil is an impurity found in treprostinil, which is a stable analog of prostaglandin I2 with a longer plasma half-life. 15-keto Treprostinil (sodium salt)  Chemical Structure
  54. GC40973 16(R)-Iloprost Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. 16(R)-Iloprost  Chemical Structure
  55. GC40974 16(S)-Iloprost Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. 16(S)-Iloprost  Chemical Structure
  56. GC41159 16,16-dimethyl Prostaglandin D2 16,16-dimethyl PGD2 is a metabolically stable synthetic analog of PGD2. 16,16-dimethyl Prostaglandin D2  Chemical Structure
  57. GC18777 16,16-dimethyl Prostaglandin E1 16,16-dimethyl PGE1 is a metabolically stable synthetic analog of PGE1. 16,16-dimethyl Prostaglandin E1  Chemical Structure
  58. GC18635 18-hydroxy-11-deoxy Corticosterone 18-hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid secreted by the zona fasciculata of the adrenal gland. 18-hydroxy-11-deoxy Corticosterone  Chemical Structure
  59. GC40457 19(R)-HETE 19-HETE is one of the major cytochrome P450 (CYP450) metabolites of arachidonic acid that is released from the kidney in response to angiotensin II. 19(R)-HETE  Chemical Structure
  60. GC40417 19-hydroxy Cholesterol 19-hydroxy Cholesterol is formed during metabolic oxidation of cholesterol. 19-hydroxy Cholesterol  Chemical Structure
  61. GC18748 1a,1b-dihomo Prostaglandin E1 Prostaglandin E1 (PGE1) is not a major naturally occurring PG, but is widely administered clinically for several indications including peripheral occlusive vascular disease, erectile dysfunction, and in neonatal cardiology. 1a,1b-dihomo Prostaglandin E1  Chemical Structure
  62. GC52122 2’-Deoxyadenosine-5’-diphosphate (sodium salt) A nucleotide diphosphate 2’-Deoxyadenosine-5’-diphosphate (sodium salt)  Chemical Structure
  63. GC42065 2,3-dinor Thromboxane B1 Thromboxane B2 (TXB2) is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2. 2,3-dinor Thromboxane B1  Chemical Structure
  64. GC49671 2,3-Oxidosqualene An intermediate in the biosynthesis of sterols 2,3-Oxidosqualene  Chemical Structure
  65. GC19560 2-(2-Phenylethyl)chromone 2-(2-Phenylethyl)chromone  Chemical Structure
  66. GC42135 2-chloro Palmitic Acid 2-chloro Palmitic acid is a monochlorinated form of palmitic acid. 2-chloro Palmitic Acid  Chemical Structure
  67. GC40503 2-HOBA 2-HOBA is an isoketal scavenger. 2-HOBA  Chemical Structure
  68. GC42189 2-oxo Clopidogrel 2-oxo Clopidogrel is an intermediary metabolite of clopidogrel. 2-oxo Clopidogrel  Chemical Structure
  69. GC41104 20-carboxy Arachidonic Acid 20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. 20-carboxy Arachidonic Acid  Chemical Structure
  70. GC41614 24-dehydro Cholesterol

    An immediate precursor of cholesterol

    24-dehydro Cholesterol  Chemical Structure
  71. GC46243 24-dehydro Cholesterol-d6 24-dehydro Cholesterol-d6  Chemical Structure
  72. GC40799 3-hydroxy-3-Methylglutaric anhydride The enzyme 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase mediates the rate-limiting step in cholesterol synthesis, converting HMG-CoA to mevalonate. 3-hydroxy-3-Methylglutaric anhydride  Chemical Structure
  73. GC52048 3-hydroxy-4-Methoxyphenethylamine (hydrochloride) A metabolite of dopamine 3-hydroxy-4-Methoxyphenethylamine (hydrochloride)  Chemical Structure
  74. GC52149 306-O12B 306-O12B  Chemical Structure
  75. GC42338 4-Aminobenzoic Acid hydrazide Myeloperoxidase is an enzyme, produced by neutrophils and other myeloid cells, that is released upon degranulation. 4-Aminobenzoic Acid hydrazide  Chemical Structure
  76. GC42405 4-hydroxy Atorvastatin (calcium salt) 4-hydroxy Atorvastatin is a metabolite of atorvastatin, an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias. 4-hydroxy Atorvastatin (calcium salt)  Chemical Structure
  77. GC18425 4-hydroxy Atorvastatin lactone 4-hydroxy Atorvastatin lactone is a metabolite of atorvastatin , an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias. 4-hydroxy Atorvastatin lactone  Chemical Structure
  78. GC42411 4-hydroxy Nonenal Alkyne 4-hydroxy Nonenal (4-HNE) is a major aldehyde produced during the lipid peroxidation of ω-6 polyunsaturated fatty acids, such as arachidonic acid and linoleic acid. 4-hydroxy Nonenal Alkyne  Chemical Structure
  79. GC52065 4-Methoxyphenyl-β-D-Glucopyranoside An aryl glycoside with ice recrystallization inhibitory activity 4-Methoxyphenyl-β-D-Glucopyranoside  Chemical Structure
  80. GC40053 5α,6α-epoxy Cholestanol An oxysterol and a metabolite of cholesterol produced by oxidation 5α,6α-epoxy Cholestanol  Chemical Structure
  81. GC40782 5(Z),11(Z),14(Z)-Eicosatrienoic Acid 5(Z),11(Z),14(Z)-Eicosatrienoic acid is a polyunsaturated fatty acid found in various natural sources including maritime pine (Pinus pinaster) seed oil (MPSO), gymnospermae leaves and seeds, and freshwater gastropods. 5(Z),11(Z),14(Z)-Eicosatrienoic Acid  Chemical Structure
  82. GC42498 5-chloro Hydrochlorothiazide 5-chloro Hydrochlorothiazide is a derivative of hydrochlorothiazide, which is a diuretic and antihypertensive agent that increases renal excretion of sodium, potassium, chloride, and bicarbonate ions by inhibiting tubular reabsorptive mechanisms. 5-chloro Hydrochlorothiazide  Chemical Structure
  83. GC45357 5-Chlorouracil   5-Chlorouracil  Chemical Structure
  84. GC40336 5-cis Carbaprostacyclin 5-cis Carbaprostacyclin is a stable analog of PGI2 and an isomer of carbaprostacyclin. 5-cis Carbaprostacyclin  Chemical Structure
  85. GC41483 5-hydroxy Propranolol 5-hydroxy Propranolol is a metabolite of propranolol, a β-adrenergic receptor antagonist. 5-hydroxy Propranolol  Chemical Structure
  86. GC42563 5-methyl-2-HOBA (hydrochloride) 5-methyl-2-HOBA is an isoketal scavenger. 5-methyl-2-HOBA (hydrochloride)  Chemical Structure
  87. GC41423 5-trans Prostaglandin E2 5-trans PGE2 occurs naturally in some gorgonian corals and is a common impurity in commercial lots of PGE1. 5-trans Prostaglandin E2  Chemical Structure
  88. GC40585 6α-Prostaglandin I1 6α-Prostaglandin I1 (6α-PGI1) is a stable Prostaglandin I2 (PGI2) analog resistant to hydrolysis in aqueous solutions. 6α-Prostaglandin I1  Chemical Structure
  89. GC49629 6β-hydroxy Prednisolone A metabolite of prednisolone 6β-hydroxy Prednisolone  Chemical Structure
  90. GC40586 6β-Prostaglandin I1 6β-PGI1 is a stable PGI2 analog resistant to hydrolysis in aqueous solutions. 6β-Prostaglandin I1  Chemical Structure
  91. GC40535 6,15-diketo-13,14-dihydro Prostaglandin F1α 6,15-diketo-13,14-dihydro PGF1α is a metabolite of PGI2. 6,15-diketo-13,14-dihydro Prostaglandin F1α  Chemical Structure
  92. GC18219 6-hydroxy Warfarin 6-hydroxy Warfarin is a metabolite of (+)-warfarin , which is a weaker vitamin K antagonist than (-)-warfarin . 6-hydroxy Warfarin  Chemical Structure
  93. GC18820 6-keto Prostaglandin E1 6-keto PGE1 is a metabolite isolated after the incubation of PGI2 with rabbit liver microsomes. 6-keto Prostaglandin E1  Chemical Structure
  94. GC40202 7α-hydroxy Cholesterol-d7

    7α-hydroxy Cholesterol-d7 is intended for use as an internal standard for the quantification of 7α-hydroxy cholesterol by GC- or LC-MS.

    7α-hydroxy Cholesterol-d7  Chemical Structure
  95. GC40201 7β-hydroxy Cholesterol-d7 7β-hydroxy Cholesterol-d7 is intended for use as an internal standard for the quantification of 7β-hydroxy cholesterol by GC- or LC-MS. 7β-hydroxy Cholesterol-d7  Chemical Structure
  96. GC46241 7-keto Cholesterol-d7

    7-keto Cholesterol is a bioactive sterol and a major oxysterol component of oxidized LDL

    7-keto Cholesterol-d7  Chemical Structure
  97. GC18737 8-iso Prostaglandin E1 Isoprostanes are a family of prostanoid molecules of non-cyclooxygenase origin. 8-iso Prostaglandin E1  Chemical Structure
  98. GC42634 9(R)-HODE cholesteryl ester 9(R)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions. 9(R)-HODE cholesteryl ester  Chemical Structure
  99. GC19460 9(S)-HODE 9(S)-HODE is produced by the lipoxygenation of linoleic acid in both plants and animals. 9(S)-HODE  Chemical Structure
  100. GC42635 9(S)-HODE cholesteryl ester 9(S)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions. 9(S)-HODE cholesteryl ester  Chemical Structure
  101. GC40338 9-deoxy-9-methylene Prostaglandin E2 9-deoxy-9-methylene Prostaglandin E2 (9-deoxy-9-methylene PGE2) is a stable, isosteric analog of PGE2. 9-deoxy-9-methylene Prostaglandin E2  Chemical Structure

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