Cardiovascular

Cardiovascular
The cardiovascular system consists of the heart, blood and blood vessels. These organs form the 3 major closed circulation systems in the body, i.e., the pulmonary, coronary and systemic circulations. Cardiovascular disease includes heart disease, vascular diseases of the brain and kidney, and peripheral arterial diseases. Cardiovascular disease is the leading cause of death globally. Studies on cardiovascular regulation are important to provide a better understanding of this group of diseases and to help improve the corresponding treatment.
Targets for Cardiovascular
Products for Cardiovascular
- Cat.No. Product Name Information
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GC45198
α-CGRP (8-37) (human) (trifluoroacetate salt)
Calcitonin Gene-Related Peptide-1 (8-37) (human), CGRP-1 (8-37) (human), α-Calcitonin Gene-Related Peptide (8-37) (human)
Calcitonin gene-related protein (CGRP) is a neuropeptide and a product of alternative splicing of the calcitonin gene. -
GC45200
α-CGRP (rat) (trifluoroacetate salt)
Calcitonin Gene-Related Peptide-1 (rat), α-Calcitonin Gene-Related Peptide (rat), CGRP-1 (rat)
α-Calcitonin gene-related peptide (α-CGRP) is a neuropeptide with roles in vasodilation, cardiovascular regulation, and inflammation. -
GC45208
α-hydroxy Metoprolol
α-hydroxy Metoprolol is an active metabolite of the β1-adrenergic receptor blocker metoprolol.
-
GC48283
α-Linolenic Acid-d14
ALAd14
An internal standard for the quantification of αLinolenic acid -
GC45602
α-Linolenic Acid-d5 MaxSpec• Standard
ALA-d5, C18:3 (9Z,12Z,15Z)-d5, C18:3 n-3-d5
-
GC49467
β-Aescin
A triterpenoid saponin with diverse biological activities
-
GC49890
β-Glycerophosphate-d5 (sodium salt hydrate)
Glycerol 2-Phosphate-d5
An internal standard for the quantification of β-glycerophosphate -
GC40105
βARK1 Inhibitor
βARK1 Inhibitor (methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate) is a GRK2 (β-ARK1) inhibitor.
-
GC52400
γ-Glu-Ala (trifluoroacetate salt)
γ-Glutamylalanine, γ-L-Glutamyl-L-alanine
A dipeptide -
GC52404
γ-Glu-Phe (trifluoroacetate salt)
γ-Glutamylphenylalanine
A dipeptide with metabolism-altering activity -
GC41393
ω-3 Arachidonic Acid methyl ester
ω-3 Fatty acids, represented primarily by docosahexaenoic acid, eicosapentaenoic acid, and α-linoleate, are essential dietary nutrients required for normal growth and development.
-
GC41661
(±)-4-hydroxy Propranolol β-D-Glucuronide
(±)-4-hydroxy Propranolol β-D-glucuronide is a metabolite of (±)-4-hydroxy propranolol, which is a metabolite of propranolol.
-
GC46273
(±)-Atenolol-d7
(R,S)-Atenolol-d7, Duraatenol, ICI 66082
An internal standard for the quantification of (±)-atenolol -
GC46289
(±)-Felodipine-d5
An internal standard for the quantification of (±)-felodipine
-
GC46304
(±)-Nebivolol-d4 (hydrochloride)
A neuropeptide with diverse biological activities
-
GC90022
(±)-Norepinephrine-d6 (hydrochloride)
An internal standard for the quantification of norepinephrine
-
GC46307
(±)-Propranolol-d7
An internal standard for the quantification of propranolol
-
GC46312
(±)-Verapamil-d3 (hydrochloride)
(±)-Verapamil-d3 hydrochloride; CP-16533-1-d3 hydrochloride
A neuropeptide with diverse biological activities -
GC40229
(±)-Warfarin-d5
(±)-Warfarin-d5 is intended for use as an internal standard for the quantification of warfarin by GC- or LC-MS.
-
GC40386
(±)11(12)-EpETE
(±)11,12-EEQ, (±)11,12-Epoxyeicosatetraenoic Acid
Eicosapentaenoic acid is converted to epoxyeicosatetraenoic acids (EpETE) by several cytochrome P450 isoforms. -
GC40467
(±)11-HETE
(±)11-Hydroxyeicosatetraenoic Acid
(±)11-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. -
GC91065
(±)13,14-EDT
A metabolite of adrenic acid
-
GC41649
(±)13-HODE cholesteryl ester
(±)13-HODE cholesteryl ester was originally extracted from atherosclerotic lesions and shown to be produced by Cu2+-catalyzed oxidation of LDL.
-
GC40268
(±)14(15)-DiHET
(±)14,15DiHETrE
Epoxide hydrolases convert the EETs into vicinal diols, with the concurrent loss of much of their biological activity. -
GC40430
(±)14(15)-EET
(±)14,15-EET, (±)14,15-EpETrE
(±)14(15)-EET is biosynthesized in rat and rabbit liver microsomes by CYP450.
-
GC40835
(±)14(15)-EET methyl ester
(±)14,15EpETrE methyl ester
(±)14(15)-EET is biosynthesized in rat and rabbit liver microsomes by CYP450. -
GC41651
(±)14(15)-EET-SI
14,15-EpETrE-SI, 14(15)-EET-SI, 14(15)EETsulfonimide
Arachidonic acid is metabolized in the vascular endothelium to epoxytrienoic acids (EETs or EpETrEs) by cytochrome P450 enzymes. -
GC91067
(±)16,17-EDT
A metabolite of adrenic acid
-
GC40434
(±)16-HETE
(±)16-Hydroxyeicosatetraenoic Acid
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. -
GC46260
(±)17(18)-EpETE
(±)17,18-EEQ, (±)17,18-epoxy Eicosatetraenoic Acid
A neuropeptide with diverse biological activities -
GC41288
(±)17(18)-EpETE-Ethanolamide
17,18-EEQ-EA, (±)17,18-EEQ-Ethanolamide, (±)17(18)-EpETE-EA, 17,18-epoxy-Eicosatetraenoic Acid Ethanolamide
(±)17(18)-EpETE-Ethanolamide is an ω-3 endocannabinoid epoxide. -
GC40362
(±)18-HEPE
(±)18-HEPE is produced by non-enzymatic oxidation of EPA.
-
GC40436
(±)18-HETE
(±)18-Hydroxyeicosatetraenoic Acid
(±)18-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid. -
GC41655
(±)19(20)-EDP Ethanolamide
19,20-DHEA epoxide, 19,20-epoxy Docosapentaenoic Acid Ethanolamide, 19,20-EDP-EA, 19,20-EDP epoxide
(±)19(20)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 108 and 280 nM for CB1 and CB2, respectively). -
GC40437
(±)5(6)-DiHET lactone
(±)5,6DiHETrE lactone
5,6-DiHET lactone is a lactonized form of 5,6-EET and 5,6-DiHET. -
GC40438
(±)5(6)-EET
(±)5,6EpETrE
5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. -
GC40421
(±)8(9)-EE-14(Z)-E
(±)8,9-Epoxyeicosa-14(Z)-enoic Acid
(±)14(15)-EE-8(Z)-E is a potent vasodilator in bovine coronary arteries. -
GC41665
(±)8(9)-EET Ethanolamide
(±)8,9-EET Ethanolamide
Arachidonoyl ethanolamide (AEA; anandamide) is an endogenous lipid neurotransmitter with cannabinergic activity, binding to both the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. -
GC40443
(±)9-HETE
(±)9-Hydroxyeicosatetraenoic Acid
(±)9-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. -
GC40541
(±)9-HODE
(±)9-HODE is one of the two racemic monohydroxy fatty acids resulting from the non-enzymatic oxidation of linoleic acid.
-
GC41666
(±)9-HODE cholesteryl ester
(±)9-HODE cholesteryl ester was originally extracted from atherosclerotic lesions and shown to be produced by Cu2+-catalyzed oxidation of LDL.
-
GC40356
(±)9-HpODE
(±)9-HpODE is a racemic mixture of the fatty acid hydroperoxide product (9(S)-HpODE) formed from lipoxygenase action on linoleic acid.
-
GC70332
(+)-Erinacin A
(+)-Erinacin A is an anticancer compound that can be isolated from the mushroom Hericium erinaceum.
-
GC49690
(3R,5R)-Rosuvastatin (calcium salt)
A potential impurity found in bulk preparations of rosuvastatin
-
GC41694
(3S)-hydroxy Quinidine
(3S)-hydroxy Quinidine is an active quinidine metabolite.
-
GC48508
(4-Carboxybutyl-d4)triphenylphosphonium (bromide)
TPP-d4, 5-Triphenylphosphoniovaleric Acid-d4
An internal standard for the quantification of (4-carboxybutyl)triphenylphosphonium -
GC40444
(5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic Acid
HETE Analog 1, Hydroxyeicosatetraenoic Acid Analog 1
(5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic acid is a stable isomer of 15(S)-HETE, a major arachidonic acid metabolite from the 15-lipoxygenase pathway. -
GC41696
(Ala1)-PAR4 (1-6) (mouse) (trifluoroacetate salt)
H-Ala-Tyr-Pro-Gly-Lys-Phe-OH, AYPGKF
(Ala1)-PAR4 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 4 (PAR4) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of mouse PAR4 and residues 60-65 of the full-length sequence with an alanine residue substituted for glycine at position 1/60. -
GC41697
(Ala1)-PAR4 (1-6) amide (mouse) (trifluoroacetate salt)
AY-NH2, AYPGKF-NH2, H-Ala-Tyr-Pro-Gly-Lys-Phe-NH2, PAR4-AP, Proteinase-Activated Receptor 4 Activating Peptide
(Ala1)-PAR4 (1-6) amide (mouse) is a peptide agonist of proteinase-activated receptor 4 (PAR4) that induces aggregation of rat and human platelets in vitro (EC50s = 15 and 60 μM, respectively). -
GC49003
(E)-Ajoene
NSC 614554
A disulfide with diverse biological activities -
GC46336
(E)-Guggulsterone
A farnesoid X receptor antagonist
-
GC41704
(Glp1)-Apelin-13 (trifluoroacetate salt)
(pGlu1)Apelin13, PyrApelin13, (Pyr1)Apelin13
The apelin gene encodes a pre-proprotein that is processed to generate bioactive peptides consisting of 36, 17, or 13 amino acids: apelin-36, apelin-17, and apelin-13, respectively. -
GC40552
(R)-Acenocoumarol
(R)Acenocoumarin, (R)Nicoumalone
Acenocoumarol is a short-lived oral anti-coagulant, which, like warfarin, functions by inhibiting vitamin K epoxide reductase. -
GC41722
(R,S)-Carvedilol Glucuronide
(R,S)-Carvedilol glucuronide is a racemic mixture of the carvedilol metabolites (R)-carvedilol glucuronide and (S)-carvedilol glucuronide.
-
GC46346
(S)-(+)-Clopidogrel-d3 (sulfate)
A neuropeptide with diverse biological activities
-
GC40553
(S)-Acenocoumarol
(S)Acenocoumarin, (S)Nicoumalone
Acenocoumarol is a short-lived oral anti-coagulant, which, like warfarin, functions by inhibiting vitamin K epoxide reductase. -
GC48719
(S)-Canadine
(-)-Canadine, (S)-Tetrahydroberberine
(S)-Canadine is an alkaloid and intermediate in the biosynthesis of berberine with insecticidal activity. -
GC19824
(±)-Pinocembrin
(+)-Pinocembrin, Dihydrochrysin, NSC 279005
(±)-Pinocembrin ((±)-5,7-Dihydroxyflavanone) is a GPR120 ligand able to promote wound healing in HaCaT cell line. -
GC49034
1(R)-(Trifluoromethyl)oleyl alcohol
An oleic acid analog
-
GC92074
1,2,3-Trioleoyl Glycerol-d5
Glyceryl Trioleate-d5; TG(18:1/18:1/18:1)-d5; Triolein-d5
1,2,3-Trioleoyl glycerol-d5 is intended for use as an internal standard for the quantification of 1,2,3-trioleoyl glycerol by GC- or LC-MS. -
GC41837
1,3,7-Trimethyluric Acid
8-oxo Caffeine, NSC 11259
1,3,7-Trimethyluric acid is a methyl derivative of uric acid and a product of C-8 oxidation of caffeine by cytochrome P450 enzymes.
-
GC46387
1,3,7-Trimethyluric Acid-d9
TMU-d9, 8-oxo Caffeine-d9
An internal standard for the quantification of 1,3,7-trimethyluric acid -
GC41846
1,3-Dioctanoyl-2-Oleoyl-rac-glycerol
1,3-Caprylin-2-Olein, 1,3-Dicapryloyl-2-Oleoyl Glycerol, TG(8:0/18:1/8:0), 8:0/18:1/8:0-TG
1,3-Dioctanoyl-2-oleoyl-rac-glycerol is a triacylglycerol that contains octanoic acid at the sn-1 and sn-3 positions and oleic acid at the sn-2 position. -
GC49346
1-(3-Chlorophenyl)biguanide (hydrochloride)
m-Chlorophenylbiguanide hydrochloride, meta-Chlorophenylbiguanide, m-CPBG, meta-CPBG
A 5-HT3 receptor agonist -
GC18235
1-O-Hexadecyl-sn-glycerol
α-Chimyl Alcohol, (S)-(+)-Chimyl Alcohol
1-O-Hexadecyl-sn-glycerol is a bioactive alkyl glyceryl ether.
-
GC42008
1-Octadecyl Lysophosphatidic Acid
1Octadecyl LPA
1-Octadecyl lysophosphatidic acid (1-octadecyl LPA) is a LPA analog containing stearic acid at the sn-1 position. -
GC92019
1-Octadecyl-2-hydroxy-sn-glycero-3-phosphate (sodium salt)
LPA O-18:0; O-18:0 LPA; 1-Octadecyl-2-hydroxy-sn-glycero-3-PA; 1-Octadecyl LPA; 1-Octadecyl Lysophosphatidic Acid; 1-Oleyl LPA; 1-Oleyl Lysophosphatidic Acid; PA(O-18:0/0:0); 1-Stearyl-2-hydroxy-sn-glycero-3-PA
1-Octadecyl-2-hydroxy-sn-glycero-3-phosphate (1-Octadecyl LPA) is a LPA analog containing stearyl alcohol at the sn-1 position. -
GC49071
1-Palmitoyl-d9 Lysophosphatidic Acid
1-Palmitoyl-d9 LPA
An internal standard for the quantification of 1-palmitoyl lysophosphatidic acid -
GC46494
1-Stearoyl-2-Arachidonoyl-d11-sn-glycero-3-PC
18:0/20:4-d11-PC, PC(18:0/20:4-d11), SAPC-d11, 1-Stearoyl-2-Arachidonoyl-d11-sn-glycero-3-Phosphatidylcholine, 1-Stearoyl-2-Arachidonoyl-d11-sn-glycero-3-Phosphocholine
A neuropeptide with diverse biological activities -
GC46496
1-Stearoyl-2-Arachidonoyl-d8-sn-glycero-3-PC
18:0/20:4-d8-PC, PC(18:0/20:4-d8), SAPCd8, 1-Stearoyl-2-Arachidonoyl-d8-sn-glycero-3-Phosphatidylcholine, 1-Stearoyl-2-Arachidonoyl-d8-sn-glycero-3-Phosphocholine
An internal standard for the quantification of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PC -
GC49733
1-Stearoyl-2-eicosapentaenoyl-sn-glycero-3-PC
1-Octadecanoyl-1-Eiocosapentaenoyl-sn-glycero-3-Phosphatidylcholine, 1-Octadecanoyl-1-Eiocosapentaenoyl-sn-glycero-3-Phosphocholine, PC(18:0/20:5), 18:0/20:5-PC
A phospholipid -
GC49118
10-hydroxy Warfarin
A metabolite of (R)-warfarin
-
GC46408
11-dehydro Thromboxane B2-d4
11-dehydro TXB2-d4, 11keto TXB2d4
An internal standard for the quantification of 11dehydro thromboxane B2 -
GC18634
11-deoxy Prostaglandin E1
11deoxy PGE1
11-deoxy Prostaglandin E1 (11-deoxy PGE1) is a synthetic analog of PGE1. -
GC41401
11-deoxy Prostaglandin F1α
11deoxy PGF1α
11-deoxy PGF1α is a synthetic analog of PGF1α. -
GC41402
11-deoxy Prostaglandin F1β
9β,11deoxy PGF1α, 11deoxy PGF1β
11-deoxy PGF1β is a synthetic analog of PGF1β. -
GC92076
119-23
119-23 is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.
-
GC18637
11β-Prostaglandin F2α
9α,11βPGF2α, 11βPGF2α, 11epi PGF2α
11β-Prostaglandin F2α (11β-PGF2α) is the primary plasma metabolite of PGD2 in vivo.
-
GC41882
12(S)-HETrE
12(S)-HETrE is produced by 12-lipoxygenase oxidation of dihomo-γ-linolenic acid (DGLA).
-
GC41893
13(R)-HODE cholesteryl ester
13(R)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions.
-
GC41895
13(S)-HODE cholesteryl ester
13(S)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions.
-
GC41897
13(S)-HOTrE
13(S)-HOTrE is the 15-lipoxygenase (15-LO) product of linolenic acid.
-
GC40745
13,14-dehydro-15-cyclohexyl Carbaprostacyclin
13,14-dehydro-15-cyclohexyl Carbaprostacyclin is a chemically stable analog of PGI2.
-
GC41433
13,14-dihydro Prostaglandin E1
PGE0, 13,14-dihydro PGE1
13,14-dihydro Prostaglandin E1 (13,14-dihydro PGE1) is a biologically active metabolite of PGE1 with comparable potency to the parent compound. -
GC46421
13,14-dihydro Prostaglandin E1-d4
13,14dh PGE1d4, Prostaglandin E0D4
A neuropeptide with diverse biological activities -
GC46425
13,14-dihydro-15-keto Prostaglandin E1-d4
13,14dh15k PGE1d4
A neuropeptide with diverse biological activities -
GC40424
14,15-EE-5(Z)-E
14,15Epoxyeicosa5(Z)enoic Acid
Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity. -
GC40425
14,15-EE-8(Z)-E
14,15Epoxyeicosa8(Z)enoic Acid
Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity. -
GC46438
14S(15R)-EET
14S,15R-EpETrE
A cytochrome P450 metabolite of arachidonic acid -
GC41173
15(R)-Pinane Thromboxane A2
15-epi-Pinane Thromboxane A2, 15-iso-Pinane Thromboxane A2, 15(R)PTA2, 15-epi-PTA2, 15-iso-PTA2
15(R)-Pinane thromboxane A2 is the (R)-epimer of pinane thromboxane A2. -
GC41166
15(S)-15-methyl Prostaglandin D2
15(S)15methyl PGD2
15(S)-15-methyl Prostaglandin D2 (15(S)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2. -
GC40452
15(S)-HETE MaxSpec® Standard
15(S)-HETE is a major arachidonic acid metabolite from the 15-lipoxygenase pathway.
-
GC41102
15-deoxy-δ12,14-Prostaglandin D2
15deoxyΔ12,14PGD2
15-deoxy-δ12,14-PGD2 is a synthetic analog of PGD2 and a potential precursor to the PPARγ ligand 15-deoxy-δ12,14-PGJ2. -
GC46443
15-deoxy-δ12,14-Prostaglandin D2-d4
15-deoxy-Δ12,14-PGD2-d4
A neuropeptide with diverse biological activities -
GC46444
15-deoxy-δ12,14-Prostaglandin D2-d9
15-deoxy-Δ12,14-PGD2-d9
A neuropeptide with diverse biological activities -
GC41103
15-keto Prostaglandin A1
15keto PGA1
Prostaglandin A1 (PGA1) was first isolated as a dehydration product of the PGE1 compounds found in human semen. -
GC41935
15-keto Treprostinil (sodium salt)
15-keto Treprostinil is an impurity found in treprostinil, which is a stable analog of prostaglandin I2 with a longer plasma half-life.
-
GC40973
16(R)-Iloprost
Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin.
-
GC40974
16(S)-Iloprost
Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin.
-
GC41159
16,16-dimethyl Prostaglandin D2
16,16dimethyl PGD2
16,16-dimethyl PGD2 is a metabolically stable synthetic analog of PGD2.