GLPBio

IGF1R

IGF1R (insulin-Like growth factor 1 receptor) is a receptor tyrosine kinase that bind to insulin-like growth factor 1 with high affinity. It plays a vital role in in cell growth, cell survival and malignant transformation etc.

Products Related to IGF1R(34)

  • GC13697 structure
    GC13697AG-1024
    CAS: 65678-07-1
    Purity: >98.50%

    AG-1024 is a reversible, competitive and selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC 50 value of 7μM. AG-1024 can inhibit the phosphorylation of insulin receptor (IR) with an IC 50 value of 57μM.

  • GC16991 structure
    GC16991PQ 401
    CAS: 196868-63-0
    Purity: >99.50%

    IGF1R inhibitor,potent and cell-permeable

  • GC12273 structure
    GC12273GSK1838705A
    CAS: 1116235-97-2
    Purity: >99.00%

    GSK1838705A is a small-molecule kinase inhibitor that targets Insulin-like Growth Factor 1 Receptor (IGF-1R) and the insulin receptor, with IC₅₀ values of 2.0nM and 1.6nM, respectively.

  • GC12712 structure
    GC12712NT157
    CAS: 1384426-12-3
    Purity: >98%

    NT157 is a selective inhibitor of insulin receptor substrate-1/-2 (IRS-1/2).

  • GC12963 structure
    GC12963NVP-AEW541
    CAS: 475489-16-8
    Purity: >98.50%

    IGF-IR inhibitor, novel, potent and selective

  • GC13102 structure
    GC13102XL228
    CAS: 898280-07-4
    Purity: >99.00%

    A tyrosine kinase inhibitor

  • GC14189 structure
    GC14189AZD-3463
    CAS: 1356962-20-3
    Purity: >99.50%

    ALK/IGF1R inhibitor

  • GC14552 structure
    GC14552LDK378
    CAS: 1032900-25-6
    Purity: >99.50%

    LDK378 (LDK378) is a selective, orally bioavailable, and ATP-competitive ALK tyrosine kinase inhibitor with an IC50 of 200 pM.

  • GC15749 structure
    GC15749Linsitinib
    CAS: 867160-71-2
    Purity: >98.00%

    Linsitinib is a potent, selective, and orally bioavailable dual IGF-1R/IR kinase inhibitor, with the IC 50 values of 0.035μM, and 0.075μM, respectively.

  • GC16712 structure
    GC16712BMS-754807
    CAS: 1001350-96-4
    Purity: >98.00%

    IGF-1R/InsR inhibitor,potent and selective

  • GC16821 structure
    GC16821TAE226(NVP-TAE226)
    CAS: 761437-28-9
    Purity: >98.00%

    TAE226(NVP-TAE226) is a potent ATP-competitive inhibitor that inhibits a variety of tyrosine protein kinases, especially FAK and IGF-IR kinases, with IC 50 values ​​of 5.5nM and 140nM, respectively.

  • GC17045 structure
    GC17045AXL1717
    CAS: 477-47-4
    Purity: >99.50%

    AXL1717 is an orally active and highly selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC 50 value of 1nM.

  • GC17452 structure
    GC17452LDK378 dihydrochloride
    CAS: 1380575-43-8
    Purity: >99.50%
  • GC17612 structure
    GC17612GSK1904529A
    CAS: 1089283-49-7
    Purity: >99.00%

    Selective IGF-1R/IR inhibitor

  • GC17773 structure
    GC17773BMS-536924
    CAS: 468740-43-4
    Purity: >98.50%

    IR/IGF-1R inhibitor

  • GC25881 structure
    GC25881S961
    CAS: 1083433-49-1
    Purity: >98%

    S961 is a biosynthetic insulin receptor antagonist that inhibits cellular proliferation and colony formation in breast tumour cells.

  • GC31706 structure
    GC31706Ginsenoside Rg5
    CAS: 186763-78-0
    Purity: >98.00%

    A ginsenoside with diverse biological activities

  • GC33072 structure
    GC33072AZ7550
    CAS: 1421373-99-0
    Purity: >98%

    AZ7550 is an active metabolite of AZD9291 and inhibits the activity of IGF1R with an IC50 of 1.6 μM.

  • GC34287 structure
    GC34287AZ7550 hydrochloride
    CAS: 2309762-40-9
    Purity: >98%

    AZ7550 hydrochloride is an active metabolite of AZD9291 and inhibits the activity of IGF1R with an IC50 of 1.6 μM.

  • GC34414 structure
    GC34414AZ7550 Mesylate (AZ7550 trimesylate salt)
    Purity: >98%
  • GC36311 structure
    GC36311Indirubin Derivative E804
    CAS: 854171-35-0
    Purity: >99.50%

    Indirubin Derivative E804 is a potent inhibitor of Insulin-like Growth Factor 1 Receptor (IGF1R), with an IC50 of 0.65 μM for IGF1R.

  • GC44474 structure
    GC44474NVP-AEW541 (hydrochloride)
    CAS: 2320261-63-8
    Purity: >98.00%

    Insulin-like growth factor 1 receptor (IGF-1R) is a receptor tyrosine kinase whose activation leads to angiogenesis as well as cell proliferation, survival, transformation, and metastasis.

  • GC45789 structure
    GC45789Ceritinib-d7
    CAS: 1632484-77-5
    Purity: >99.00%

    An internal standard for the quantification of ceritinib

  • GC61111 structure
    GC61111NBI-31772 hydrate
    Purity: >98.00%

    NBI-31772 hydrate is a potent inhibitor of interaction between insulin-like growth factor (IGF) and IGF-binding proteins (IGFBPs).