GLPBio

IIIM-1270

Catalog No.: GC79412Purity:>98.50%
COASDSData Sheet
IIIM-1270is a NLRP3 inflammasome inhibitor.

Products are for research use only. Not for human use. We do not sell to patients.

IIIM-1270
Cas No.: 4818-19-3
10mM (in 1mL DMSO)In Stock
$103.00
1
5mgIn Stock
$94.00
1
10mgIn Stock
$151.00
1
25mgIn Stock
$295.00
1
50mgIn Stock
$468.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

No citations are currently available for this product. Below are selected publications citing GlpBio products.
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    Nature
    641, 529–536 (2025)
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    628, 630–638 (2024)
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    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    387(6739) (2025)
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    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Description

IIIM-1270is a NLRP3 inflammasome inhibitor. IIIM-1270 inhibits IL-1β release in mouse macrophages (J774A.1 cells) ( IC50 = 3.5 μM) and significantly reduced the protein expression level of mature IL-1β. IIIM-1270 can be used for the study of inflammation [1].

References:
[1]. Abdullaha M, et al. Discovery of benzo[cd]indol-2-one and benzylidene-thiazolidine-2,4-dione as new classes of NLRP3 inflammasome inhibitors via ER-β structure based virtual screening. Bioorg Chem. 2020 Jan;95:103500.

Product Documents

Purity:>98.50%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
4818-19-3
Molecular Formula
C12H11NO2S
Molecular Weight
233.29
Solubility
DMSO: 25 mg/mL (107.16 mM; Need ultrasonic)
Storage
Store at -20°C
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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