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NOD-like Receptor (NLR)

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Nucleotide oligomerization domain (NOD)-like receptors (NLRs) are a specialized group of intracellular proteins that play a critical role in the regulation of the host innate immune response. NLRs act as scaffolding proteins that assemble signaling platforms that trigger nuclear factor-κB and mitogen-activated protein kinase signaling pathways and control the activation of inflammatory caspases. Importantly, mutations in several members of the NLR family have been linked to a variety of inflammatory diseases consistent with these molecules playing an important role in host-pathogen interactions and the inflammatory response. NLRs including Nod1 and Nod2 are thought to be kept in an inactive state by intra-molecular interactions.

The central role of the Nod-like receptor (NLR) protein family became increasingly appreciated in innate immune responses. NLRs are classified as part of the signal transduction ATPases with numerous domains (STAND) clade within the AAA+ ATPase family.

Products Related to NOD-like Receptor (NLR)(66)

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    GC10634MCC950 sodium
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    MCC950 sodium is a novel, orally active NLRP3 inflammasome inhibitor (IC 50 =7.5nM-8.1nM).

  • GC15811 structure
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  • GC15933 structure
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  • GC16641 structure
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    ML130 (Nodinitib-1) (ML130;CID-1088438) is a NOD1 inhibitor with an IC50 of 0.56 μM.

  • GC17718 structure
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    Muscone is a bioactive component of musk and acts as a potent anti-inflammatory agent, reducing proinflammatory cytokines and end-plate degeneration .

  • GC18071 structure
    GC18071CORM-3
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  • GC19113 structure
    GC19113CY-09
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  • GC19201 structure
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    INF39 is an irreversible and noncytotoxic NLRP3 inhibitor.

  • GC31644 structure
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  • GC31657 structure
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  • GC34555 structure
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  • GC35385 structure
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  • GC38059 structure
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  • GC39311 structure
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  • GC39719 structure
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  • GC40928 structure
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  • GC50342 structure
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  • GC50556 structure
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  • GC50569 structure
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  • GC50611 structure
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  • GC60887 structure
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  • GC60958 structure
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    Purity: >99.50%

    JC-171 is a selective NLRP3 inflammasome inhibitor, with an IC50 of 8.45 μM for inhibiting LPS/ATP-induced interleukin-1β (IL-1β) release from J774A.1 macrophages.

  • GC61284 structure
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    Purity: >99.50%

    Soyasaponin II is a saponin with antiviral activity.

  • GC62300 structure
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