Imidazoline Receptors
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Imidazoline receptors are the primary receptors on which clonidine and other imidazolines act. There are three classes of imidazoline receptors: I1 receptor – mediates the sympatho-inhibitory actions of imidazolines to lower blood pressure, (NISCH or IRAS, imidazoline receptor antisera selected), I2 receptor - an allosteric binding site of monoamine oxidase and is involved in pain modulation and neuroprotection, I3 receptor - regulates insulin secretion from pancreatic beta cells. Activated I1-imidazoline receptors trigger the hydrolysis of phosphatidylcholine into DAG. Elevated DAG levels in turn trigger the synthesis of second messengers arachidonic acid and downstreameicosanoids. In addition, the sodium-hydrogen antiporter is inhibited, and enzymes of catecholamine synthesis are induced. The I1-imidazoline receptor may belong to the neurocytokine receptorfamily, since its signaling pathways are similar to those of interleukins.
Products Related to Imidazoline Receptors(18)
- GC11198Moxonidine hydrochlorideCAS: 75536-04-8Purity: >98%
Mixed I1 imidazoline receptor and α2-adrenergic agonist
- GC115882-BFI hydrochlorideCAS: 89196-95-2Purity: >98.00%
2-BFI hydrochloride is a high-affinity, selective agonist of the imidazoline I2 receptor (I2R) with a Ki of 70.1nM.
- GC12629MoxonidineCAS: 75438-57-2Purity: >98.00%
An imidazoline I 1 and α 2A -adrenergic receptor agonist
- GC13017Rilmenidine PhosphateCAS: 85409-38-7Purity: >98.00%
antihypertensive drug targets the imidazoline receptor
- GC14958RS 45041-190 hydrochlorideCAS: 204274-74-8Purity: >98%
Highly selective I2 imidazoline receptor ligand
- GC15202BU 226 hydrochlorideCAS: 1186195-56-1Purity: >98%
Ligand at I2 imidazoline sites,high affinity and selectivity
- GC15700BU 224 hydrochlorideCAS: 205437-64-5Purity: >98.00%
Antagonist of I2 Imidazoline receptor,potent and selective
- GC69206Harmane-dPurity: >98.00%
Harmane-d is the deuterated form of Harmane. Harmane, a beta-carboline alkaloid, is an effective neurotoxin that can cause severe motor tremors and psychiatric symptoms. Harmane has a 1000-fold selectivity for I1-imidazoline receptors (IC50=30 nM) over alpha-2 adrenergic receptors (IC50=18 μM). It is also an effective and selective monoamine oxidase inhibitor with IC50 values of 0.5 μM and 5 μM for MAO A/B, respectively.
- GC74240Allantoin-13C2,15N4CAS: 1219402-51-3Purity: >99.00%
Allantoin-13C2,15N4 is the 13C and 15N labeled Allantoin.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC11198 | Moxonidine hydrochloride | 75536-04-8 | >98% | |
Mixed I1 imidazoline receptor and α2-adrenergic agonist | ||||
| GC11580 | BU 239 hydrochloride | 1217041-98-9 | >98% | |
Imidazoline receptors-selective antagonist | ||||
| GC11588 | 2-BFI hydrochloride | 89196-95-2 | >98.00% | |
2-BFI hydrochloride is a high-affinity, selective agonist of the imidazoline I2 receptor (I2R) with a Ki of 70.1nM. | ||||
| GC12629 | Moxonidine | 75438-57-2 | >98.00% | |
An imidazoline I 1 and α 2A -adrenergic receptor agonist | ||||
| GC13017 | Rilmenidine Phosphate | 85409-38-7 | >98.00% | |
antihypertensive drug targets the imidazoline receptor | ||||
| GC14934 | AGN 192403 hydrochloride | 1021868-90-5 | >98.00% | |
I1 imidazoline receptor | ||||
| GC14958 | RS 45041-190 hydrochloride | 204274-74-8 | >98% | |
Highly selective I2 imidazoline receptor ligand | ||||
| GC15202 | BU 226 hydrochloride | 1186195-56-1 | >98% | |
Ligand at I2 imidazoline sites,high affinity and selectivity | ||||
| GC15384 | Harmane | 486-84-0 | >99.50% | |
endogenous ligand for imidazoline binding sites | ||||
| GC15700 | BU 224 hydrochloride | 205437-64-5 | >98.00% | |
Antagonist of I2 Imidazoline receptor,potent and selective | ||||
| GC16831 | Agmatine sulfate | 2482-00-0 | >98.00% | |
α2-adrenergic receptor ligand | ||||
| GC31094 | CR4056 | 1004997-71-0 | >98% | |
| GC38192 | Idazoxan hydrochloride | 79944-56-2 | >98% | |
| GC60325 | Rilmenidine | 54187-04-1 | >98% | |
An antihypertensive agent | ||||
| GC63754 | Harmane-d1 | - | >95.00% | |
Harmane-d1 is the deuterium labeled Harmane. | ||||
| GC69206 | Harmane-d | - | >98.00% | |
Harmane-d is the deuterated form of Harmane. Harmane, a beta-carboline alkaloid, is an effective neurotoxin that can cause severe motor tremors and psychiatric symptoms. Harmane has a 1000-fold selectivity for I1-imidazoline receptors (IC50=30 nM) over alpha-2 adrenergic receptors (IC50=18 μM). It is also an effective and selective monoamine oxidase inhibitor with IC50 values of 0.5 μM and 5 μM for MAO A/B, respectively. | ||||
| GC74240 | Allantoin-13C2,15N4 | 1219402-51-3 | >99.00% | |
Allantoin-13C2,15N4 is the 13C and 15N labeled Allantoin. | ||||
| GN10492 | Allantoin | 97-59-6 | >99.50% | |