GLPBio

Immunoproteasome activator 1

Catalog No.: GC83255Purity:>99.50%
COASDSData Sheet
Immunoproteasome activator 1 (compound A) is a selective immunoproteasome activator that increases the presentation of individual MHC-I –bound peptides by over 100-fold.

Products are for research use only. Not for human use. We do not sell to patients.

Immunoproteasome activator 1
Cas No.: 901728-48-1
1mgIn Stock
$203.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

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  • Nature cover
    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
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    387(6739) (2025)
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    Science
    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    Cell Research
    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    Cell Research
    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

Description

Immunoproteasome activator 1 (compound A) is a selective immunoproteasome activator that increases the presentation of individual MHC-I –bound peptides by over 100-fold. Immunoproteasome activator 1 binds to the proteasome structural subunit PSMA1 and promotes the association of the proteasome activator PA28α/β (PSME1/PSME2) with immunoproteasomes [1].

References:
[1]. Rana PS, et al. Immunoproteasome activation expands the MHC class I immunopeptidome, unmasks neoantigens and enhances T-cell antimyeloma activity. Mol Cancer Ther. 2024 Aug 30.

Product Documents

Purity:>99.50%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
901728-48-1
Molecular Formula
C24H23N3O3
Molecular Weight
401.46
Storage
Store at -20°C
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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