GLPBio

Proteasome

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The proteasome is a large multisubunit complex of approximately 2.5 MDa that mediates a wide range of physiological and pathological cellular processes by selectively degrading unnecessary proteins in eukaryotes. The structure of a proteasome is comprised of the catalytic core particle (CP) and two terminal regulatory particles (RPs). The CP (also known as the 20S proteasome) is a barrel shaped multisubunit complex (approximately 750 kDa) consisting of four axially stacked heptameric rings (two outer α-rings and two inner β-rings) with 7 subunits in each ring, where three β subunits (β1, β2 and β5) contain catalytically active threonine residues and are associated with caspase-like, trypsin-like and chymotrypsin-like activities respectively.

Products Related to Proteasome(77)

  • GC12003 structure
    GC12003VR23
    CAS: 1624602-30-7
    Purity: >99.00%

    proteasome inhibitor

  • GC15802 structure
    GC15802PI-1840
    CAS: 1401223-22-0
    Purity: >99.00%

    Chymotrypsin-like (CT-L) inhibitor

  • GA20483 structure
    GA20483Ac-Arg-Leu-Arg-AMC
    CAS: 929903-87-7
    Purity: >98%

    Ac-Arg-Leu-Arg-AMC is a fluorescent peptide substrate (excitation/emission wavelength=380/440-460nm) used to detect the trypsin-like activity of the 26S proteasome.

  • GC10102 structure
    GC10102Aclacinomycin A
    CAS: 57576-44-0
    Purity: ≥95%

    An anthracycline with antibiotic and anticancer activities

  • GC10178 structure
    GC10178MG-115
    CAS: 133407-86-0
    Purity: >98.00%

    MG-115 is a potent inhibitor with Kis of 21 nM and 35 nM for 20S and 26S proteasome, respectively.

  • GC10342 structure
    GC10342Calpeptin
    CAS: 117591-20-5
    Purity: >98.00%

    Calpeptin is a reversible and cell-permeable cysteine cathepsin inhibitor. The ID 50 values of Calpeptin for calpain I and II (porcine), papain, and platelet calpain I are 52nM, 34nM, 138nM, and 20nM, respectively. Calpeptin alleviates apoptosis and secondary inflammatory changes in muscle cells.

  • GC10383 structure
    GC10383MG-132
    CAS: 133407-82-6
    Purity: >98.00%

    MG-132 is a potent proteasome and calpain inhibitor with IC 50 values of 100nM and 1.25μM, respectively.

  • GC10486 structure
    GC10486Salinosporamide A (NPI-0052, Marizomib)
    CAS: 437742-34-2
    Purity: >98.00%

    Salinosporamide A (NPI-0052, Marizomib) is a 20S proteasome inhibitor isolated from the obligate marine actinobacterium Salinispora tropica , exhibiting potent antitumor activity with an IC 50 value of 1.3nM.

  • GC10561 structure
    GC10561PD 151746
    CAS: 179461-52-0
    Purity: >98%

    calpain inhibitor, cell-permeable

  • GC11640 structure
    GC11640MDL 28170
    CAS: 88191-84-8
    Purity: >97.00%

    MDL 28170, a cell permeable, reversible, peptidic aldehyde inhibitor of calpain (K i = 0.01μM; K i for cathepsin B = 0.025μM).

  • GC11974 structure
    GC11974Pepstatin A
    CAS: 26305-03-3
    Purity: >98.50%

    Pepstatin A is an orally active inhibitor of aspartic proteases, which is produced by actinomycetes.

  • GC12272 structure
    GC12272CEP-18770
    CAS: 847499-27-8
    Purity: >98.00%

    An inhibitor of chymotrypsin-like proteasome activity

  • GC12494 structure
    GC12494Epoxomicin
    CAS: 134381-21-8
    Purity: >98.50%

    Epoxomicin is a selective proteasome inhibitor that effectively inhibits the chymotrypsin-like (CH-L) activity of the 20S proteasome, with an IC 50 of approximately 40-80nM.

  • GC12527 structure
    GC12527MG-101 (Calpain Inhibitor I, ALLN)
    CAS: 110044-82-1
    Purity: >98.00%

    MG-101 (Calpain Inhibitor I, ALLN) also known as Calpain Inhibitor I, selectively inhibits various cysteine proteases, including calpain I, calpain II, cathepsin B, and cathepsin L. The corresponding Ki values for these enzymes are 90pM, 220pM, 150pM, and 500pM.

  • GC12784 structure
    GC12784Artemether (SM-224)
    CAS: 71963-77-4
    Purity: >98.00%

    An antiparasitic compound

  • GC13123 structure
    GC13123Lactacystin (Synthetic)
    CAS: 133343-34-7
    Purity: >95.00%

    A selective inhibitor of the 20S proteasome

  • GC13711 structure
    GC13711Gabexate mesylate
    CAS: 56974-61-9
    Purity: >98.00%

    A serine protease inhibitor

  • GC13718 structure
    GC13718MLN9708
    CAS: 1201902-80-8
    Purity: >98.00%

    A prodrug form of MLN2238

  • GC13789 structure
    GC13789AM 114
    CAS: 856849-35-9
    Purity: >98.50%
  • GC13865 structure
    GC13865PSI
    CAS: 158442-41-2
    Purity: >98%
  • GC15083 structure
    GC15083Celastrol
    CAS: 34157-83-0
    Purity: >99.50%

    Celastrol is a proteasome inhibitor with a potent and preferred inhibition of purified 20S proteasome with an IC 50 of 2.5 μM.

  • GC15089 structure
    GC15089Carfilzomib (PR-171)
    CAS: 868540-17-4
    Purity: >99.00%

    Carfilzomib (PR-171) is a next-generation tetrapeptide epoxyketone proteasome inhibitor (IC 50 =5nM).

  • GC15447 structure
    GC15447Oprozomib (ONX-0912)
    CAS: 935888-69-0
    Purity: >99.50%

    An orally available proteasome inhibitor

  • GC15517 structure
    GC15517MG-262
    CAS: 179324-22-2
    Purity: >98%

    A proteasome inhibitor with diverse biological activities